Kimura Kazutaka, Tomiyama Hirofumi, Matsumoto Chisa, Odaira Mari, Shiina Kazuki, Nagata Mikio, Yamashina Akira
Department of Cardiology, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Tokyo, Japan.
Kajima Corporation, 1-3-1 Motoakasaka, Minatoku, Tokyo, Japan.
Atherosclerosis. 2015 Dec;243(2):486-92. doi: 10.1016/j.atherosclerosis.2015.10.002. Epub 2015 Oct 8.
The progression of arterial stiffness is accelerated by aging, although the underlying mechanisms have not yet been clarified. This prospective observational study was conducted to clarify whether longitudinal changes in the serum calcium/phosphate levels are associated with the accelerated progression of arterial stiffness with age.
In a cohort of employees at a construction company (1507 middle-aged Japanese men), the serum calcium/phosphate levels and brachial-ankle pulse wave velocity (baPWV) were measured at the start and at the end of a 3-year study period.
A general linear model multivariate analysis revealed a significant interaction of the 2 factors {age and longitudinal changes of the serum calcium levels (delCa) during the follow-up period} on the longitudinal changes of the baPWV during the study period (delPWV). The delCa was significantly correlated with the delPWV even after adjustments for covariates in subjects aged ≥48 years. The delPWV in subjects aged ≥48 years with the delCa in the upper tertile (69 ± 137 cm/s) was significantly larger than that in the other groups even after adjustments for covariates (e.g., del PWV in subjects aged <48 years with the delCa in the lower tertile = 1 ± 94 cm/s) (p < 0.01).
The association between the arterial stiffness and serum calcium levels differed with age. Pathophysiological abnormalities related to increased serum calcium levels appeared to be associated with accelerated progression of arterial stiffness with age.
尽管动脉僵硬度进展加速的潜在机制尚未阐明，但衰老会加速这一进程。本前瞻性观察性研究旨在明确血清钙/磷水平的纵向变化是否与动脉僵硬度随年龄加速进展相关。
在一家建筑公司的员工队列（1507名中年日本男性）中，于3年研究期开始和结束时测量血清钙/磷水平及臂踝脉搏波速度（baPWV）。
一般线性模型多变量分析显示，在研究期间baPWV的纵向变化（delPWV）上，年龄和随访期间血清钙水平的纵向变化（delCa）这两个因素存在显著交互作用。即使在对年龄≥48岁的受试者进行协变量调整后，delCa仍与delPWV显著相关。年龄≥48岁且delCa处于上三分位数的受试者的delPWV（69±137cm/s），即使在进行协变量调整后（例如，年龄<48岁且delCa处于下三分位数的受试者的delPWV = 1±94cm/s），仍显著高于其他组（p<0.01）。
动脉僵硬度与血清钙水平之间的关联因年龄而异。与血清钙水平升高相关的病理生理异常似乎与动脉僵硬度随年龄加速进展有关。
