Holzman P S
Harvard University, Department of Psychology, Cambridge, MA 02138.
Eur Arch Psychiatry Neurol Sci. 1989;239(1):43-8. doi: 10.1007/BF01739743.
Eye movement dysfunctions have been found in a large number of schizophrenic patients and in about half of their first-degree relatives. The distribution of these traits within the families of schizophrenic patients suggests a model of genetic transmission that fits an autosomal dominant model, which we have called the "genetic latent trait model." The model, with seven parameters, was fitted to a U.S. population and the model was cross-validated on an independent Norwegian sample. Although the model does not invalidate other, more conventional solutions to the puzzle of schizophrenic transmission, such as multifactorial transmission, the latent trait model does more easily permit linkage studies and therefore will allow refutation or support from the use of molecular genetics techniques.
在大量精神分裂症患者及其约一半的一级亲属中发现了眼球运动功能障碍。这些特征在精神分裂症患者家族中的分布表明了一种符合常染色体显性模型的遗传传递模式，我们将其称为“遗传潜在特质模型”。该模型有七个参数，已应用于美国人群，并在一个独立的挪威样本上进行了交叉验证。虽然该模型并没有否定其他更传统的精神分裂症遗传传递问题的解决方案，如多因素传递，但潜在特质模型更容易进行连锁研究，因此将能够通过分子遗传学技术得到反驳或支持。
