Holzman P S, Kringlen E, Matthysse S, Flanagan S D, Lipton R B, Cramer G, Levin S, Lange K, Levy D L
Department of Psychology, Harvard University, Cambridge, Mass 02138.
Arch Gen Psychiatry. 1988 Jul;45(7):641-7. doi: 10.1001/archpsyc.1988.01800310049006.
Eye movement dysfunctions (EMDs), detectable during smooth pursuit, occur in a majority of schizophrenics and in 45% of their first-degree relatives. Previous data suggest that they represent a biologic marker for schizophrenia. To determine the mode of transmission of the schizophrenia-EMD complex, the eye movements of offspring of monozygotic and dizygotic twins were recorded. One group of twins was discordant for schizophrenia; the other group for manic depression or reactive psychosis. The data suggest that EMDs and at least some schizophrenias can be considered expressions of a single underlying trait that is transmitted by an autosomal dominant gene.
眼球运动功能障碍（EMD）在平稳追踪过程中可被检测到，大多数精神分裂症患者以及45%的一级亲属中存在该症状。先前的数据表明，它们是精神分裂症的生物学标志物。为了确定精神分裂症 - EMD复合体的遗传模式，记录了同卵双胞胎和异卵双胞胎后代的眼球运动情况。一组双胞胎中，一方患有精神分裂症，另一方没有；另一组双胞胎中，一方患有躁狂抑郁症或反应性精神病，另一方没有。数据表明，EMD和至少部分精神分裂症可被视为由常染色体显性基因传递的单一潜在特征的表现形式。
