Shin Gye Hwa, Li Jinglei, Cho Jin Hun, Kim Jun Tae, Park Hyun Jin
College of Life Sciences & Biotechnology, Korea Univ, Anam-dong, Seongbuk-gu, Seoul, 136-701, Korea.
Woongjin Co., Ltd. Changgyeonggung-ro, Jongro-gu, Seoul, 03130, Korea.
J Food Sci. 2016 Feb;81(2):N494-501. doi: 10.1111/1750-3841.13208. Epub 2016 Jan 13.
Nanosuspensions (NSs) were fabricated to enhance water solubility, dissolution rate, and oral adsorption of water insoluble curcumin using sonoprecipitation method. As a good stabilizer, d-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) was used to improve the stability of curcumin-TPGS NSs (Cur-TPGS NSs). Ultrasonic homogenization (UH) could effectively enhance the solubility of curcumin and to produce homogeneous NSs with small particle sizes. Water solubility of curcumin was significantly improved from 0.6 μg/mL in pure water to 260 μg/mL in the mixture of curcumin and TPGS (1:10) with UH treatment. The mean particle size of Cur-TPGS NSs was decreased significantly after UH and maintained between 208 and 246 nm. Lyophilized powder of Cur-TPGS NSs was dissolved about 91.08% whereas the pristine curcumin powder was dissolved only 6.5% at pH 7.4. This study showed a great potential of Cur-TPGS NSs as a good nano-formulation of curcumin with enhanced solubility and improved oral adsorption.
采用超声沉淀法制备纳米混悬液（NSs），以提高水不溶性姜黄素的水溶性、溶解速率和口服吸收性。作为一种良好的稳定剂，聚乙二醇1000维生素E琥珀酸酯（TPGS）用于提高姜黄素-TPGS纳米混悬液（Cur-TPGS NSs）的稳定性。超声均质化（UH）可有效提高姜黄素的溶解度，并制备出粒径小且均匀的纳米混悬液。经UH处理后，姜黄素在纯水中的溶解度从0.6μg/mL显著提高至在姜黄素与TPGS（1:10）混合物中的260μg/mL。UH处理后，Cur-TPGS NSs的平均粒径显著减小，并维持在208至246nm之间。在pH 7.4条件下，Cur-TPGS NSs冻干粉的溶解率约为91.08%，而原始姜黄素粉的溶解率仅为6.5%。本研究表明，Cur-TPGS NSs作为一种良好的姜黄素纳米制剂，具有增强的溶解度和改善的口服吸收潜力。
