Reverchon Ernesto, Scognamiglio Mariarosa, Baldino Lucia
Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, SA, Italy.
Nanomaterials (Basel). 2022 Apr 19;12(9):1401. doi: 10.3390/nano12091401.
Traditional and supercritical CO assisted processes are frequently used to produce microparticles formed by a biopolymer containing an active principle to improve the bioavailability of the active principle. However, information about the internal organization of these microparticles is still scarce. In this work, a suspension of dextran + FeO nanoparticles (model system) and a solution of polyvinylpyrrolidone (PVP) + curcumin were used to produce spherical microparticles by supercritical CO processing. Periodic dynamic light scattering measurements were used to analyze the evolution of the microparticles dissolution, size, and size distribution of the guest active principle in the polymeric matrix. It was found that curcumin was dispersed in the form of nanoparticles in the PVP microparticles, whose size largely depended on its relative concentration. These results were validated by transmission electron microscopy and scanning electron microscopy of the PVP microparticles and curcumin nanoparticles, before and after the dissolution tests.
传统的和超临界CO辅助工艺经常用于制备由含有活性成分的生物聚合物形成的微粒，以提高活性成分的生物利用度。然而，关于这些微粒内部结构的信息仍然很少。在这项工作中，使用葡聚糖+FeO纳米颗粒的悬浮液（模型体系）和聚乙烯吡咯烷酮（PVP）+姜黄素的溶液，通过超临界CO工艺制备球形微粒。采用周期性动态光散射测量来分析微粒在聚合物基质中的溶解、尺寸以及客体活性成分的尺寸分布的演变。结果发现，姜黄素以纳米颗粒的形式分散在PVP微粒中，其尺寸在很大程度上取决于其相对浓度。在溶解试验前后，通过对PVP微粒和姜黄素纳米颗粒进行透射电子显微镜和扫描电子显微镜观察，验证了这些结果。
