Ahmed Geraldine M, Abouauf Eman A, AbuBakr Nermeen, Fouad Asmaa M, Dörfer Christof E, Fawzy El-Sayed Karim M
Stem Cell and Tissue Engineering Research Group, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Department of Endodontics, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Stem Cells Int. 2021 Sep 29;2021:8483668. doi: 10.1155/2021/8483668. eCollection 2021.
Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of the major health problems worldwide. Two regenerative therapies were introduced for a fully functional pulp-dentin complex regeneration, namely, cell-based (cell transplantation) and cell homing (through revascularization or homing by injection of stem cells in situ or intravenously) therapies, with each demonstrating advantages as well as drawbacks, especially in clinical application. The present review is aimed at elaborating on these two techniques in the treatment of irreversibly inflamed or necrotic pulp, which is aimed at regenerating a fully functional pulp-dentin complex.
再生牙科为受损牙体组织的替代开创了一个新时代。无论致病因素是龋齿、外伤还是化学损伤，牙髓活力丧失都是全球主要的健康问题之一。为实现功能完全的牙髓-牙本质复合体再生，引入了两种再生疗法，即基于细胞的（细胞移植）和细胞归巢（通过血管再生或原位或静脉注射干细胞归巢）疗法，每种疗法都有其优缺点，尤其是在临床应用中。本综述旨在阐述这两种技术在治疗不可逆性炎症或坏死牙髓方面的应用，其目的是再生出功能完全的牙髓-牙本质复合体。
