Karataş Toğral Arzu, Seçkin Deniz
Department of Dermatology, Başkent University Faculty of Medicine, Ankara, Turkey.
Australas J Dermatol. 2017 Aug;58(3):228-230. doi: 10.1111/ajd.12445. Epub 2016 Jan 14.
A 69-year-old woman with a 12-month history of asymptomatic erythematous, non-scaly, annular and arciform plaques on her face, trunk and extremities is presented. The skin lesions had been unresponsive to treatment with systemic corticosteroids and antihistamines. Skin biopsy demonstrated superficial and deep dermal inflammatory infiltration consisting mainly of eosinophils and a few neutrophils. Dermal interstitial mucin deposition was also detected in the absence of vasculitis, flame figures or granulomatous reaction. The patient was diagnosed as having eosinophilic annular erythema and treated with hydroxychloroquine (2 × 200 mg/day, p.o.). Response to treatment was observed after 7 weeks and full recovery was achieved after 10 weeks. Eosinophilic annular erythema is rarely reported in the literature. Although hydroxychloroquine is a good choice for treatment, response time can vary between patients.
本文报告了一位69岁女性，其面部、躯干和四肢出现无症状性红斑、无鳞屑、环形及弧形斑块，病程12个月。皮肤病变对全身用皮质类固醇和抗组胺药治疗无反应。皮肤活检显示真皮浅层和深层有炎症浸润，主要由嗜酸性粒细胞和少量中性粒细胞组成。在无血管炎、火焰状图形或肉芽肿反应的情况下，还检测到真皮间质粘蛋白沉积。该患者被诊断为嗜酸性环形红斑，并接受羟氯喹治疗（口服，2×200mg/天）。7周后观察到治疗反应，10周后完全康复。嗜酸性环形红斑在文献中报道较少。虽然羟氯喹是治疗的良好选择，但患者之间的反应时间可能有所不同。
