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冠状动脉疾病患者瘦素浓度的预测因素及其与心血管风险的关联：动脉粥样基因研究结果

Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study.

作者信息

Bickel Christoph, Schnabel Renate B, Zeller Tanja, Lackner Karl J, Rupprecht Hans J, Blankenberg Stefan, Sinning Christoph, Westermann Dirk

机构信息

a Department of Internal Medicine , Federal Armed Forces Central Hospital , Koblenz , Germany.

b Department of General and Interventional Cardiology , University Heart Center Hamburg , Hamburg , Germany.

出版信息

Biomarkers. 2017 May-Jun;22(3-4):210-218. doi: 10.3109/1354750X.2015.1130745. Epub 2016 Jan 15.

DOI:10.3109/1354750X.2015.1130745
PMID:26769430
Abstract

CONTEXT

Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.

OBJECTIVE

The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N = 1907).

METHODS

AtheroGene is a contemporary CAD cohort study (N = 3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.

RESULTS

Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR = 1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.

CONCLUSION

In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.

摘要

背景

瘦素在白色脂肪组织中产生，但在人类冠状动脉粥样硬化病变中也有产生。

目的

本研究旨在评估瘦素在确诊为冠心病（CAD）患者（N = 1907）中的预后价值。

方法

AtheroGene是一项当代CAD队列研究（N = 3229）。中位随访时间为3.8（四分位数1/3为2.8/4.9）年。

结果

在完全调整模型中，瘦素浓度与女性的风险比（HR）为HR = 1.32相关，但在男性中不显著。167例患者出现心血管死亡和非致命性心肌梗死的终点事件。

结论

在已知患有CAD的女性中，瘦素浓度升高有助于预测心血管死亡和非致命性心肌梗死。

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