Cellular and Molecular Cardiology Unit and Department of Cardiology, Institute of Biomedical Research of Santiago de Compostela (IDIS-SERGAS), Travesía Choupana s/n, 15706 Santiago de Compostela, Spain.
CIBERCV, Institute of Health Carlos III, C/Monforte de Lemos 3-5, Pabellón 11, Planta 0, 28029 Madrid, Spain.
Int J Mol Sci. 2020 Oct 18;21(20):7711. doi: 10.3390/ijms21207711.
It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases.
众所周知，脂肪组织除了其储能功能外，还充当内分泌器官，产生和分泌许多生物活性物质，包括通常称为脂肪因子的激素。肥胖是心血管疾病发展的主要危险因素，主要是由于这种状态下低度炎症和过多脂肪堆积所致。肥胖症中脂肪组织功能障碍导致脂肪因子异常释放，其中一些具有直接的心血管和炎症调节功能。炎症是肥胖症和心血管疾病之间的共同联系，因此，本综述将总结主要脂肪因子在调节心血管疾病发生的炎症过程中的作用。
