Fouda Abdelrahman Y, Artham Sandeep, El-Remessy Azza B, Fagan Susan C
Charlie Norwood VA Medical Center, and Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, and Georgia Regents University, Augusta, GA 30912, U.S.A. Clinical Pharmacy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Charlie Norwood VA Medical Center, and Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, and Georgia Regents University, Augusta, GA 30912, U.S.A.
Clin Sci (Lond). 2016 Feb;130(4):221-38. doi: 10.1042/CS20150350.
As our knowledge expands, it is now clear that the renin-angiotensin (Ang) system (RAS) mediates functions other than regulating blood pressure (BP). The RAS plays a central role in the pathophysiology of different neurovascular unit disorders including stroke and retinopathy. Moreover, the beneficial actions of RAS modulation in brain and retina have been documented in experimental research, but not yet exploited clinically. The RAS is a complex system with distinct yet interconnected components. Understanding the different RAS components and their functions under brain and retinal pathological conditions is crucial to reap their benefits. The aim of the present review is to provide an experimental and clinical update on the role of RAS in the pathophysiology and treatment of stroke and retinopathy. Combining the evidence from both these disorders allows a unique opportunity to move both fields forward.
随着我们知识的扩展，现在很清楚肾素-血管紧张素（Ang）系统（RAS）介导的功能不仅仅是调节血压（BP）。RAS在包括中风和视网膜病变在内的不同神经血管单元疾病的病理生理学中起着核心作用。此外，RAS调节在大脑和视网膜中的有益作用已在实验研究中得到证实，但尚未在临床上得到应用。RAS是一个复杂的系统，其组成部分各不相同但相互关联。了解大脑和视网膜病理条件下不同的RAS组成部分及其功能对于获得它们的益处至关重要。本综述的目的是提供关于RAS在中风和视网膜病变的病理生理学及治疗中的作用的实验和临床最新进展。结合这两种疾病的证据为推动这两个领域的发展提供了独特的机会。
