酿酒酵母DNA错配修复基因PMS1的克隆与核苷酸序列：PMS1与原核生物MutL和HexB的同源性
Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB.
作者信息
Kramer W, Kramer B, Williamson M S, Fogel S
机构信息
Department of Genetics, University of California, Berkeley 94720.
出版信息
J Bacteriol. 1989 Oct;171(10):5339-46. doi: 10.1128/jb.171.10.5339-5346.1989.
Abstract
The PMS1 gene from Saccharomyces cerevisiae, implicated in DNA mismatch repair in yeast cells (M. S. Williamson, J. C. Game, and S. Fogel, Genetics 110:609-646, 1985), was cloned, and the nucleotide sequence was determined. The nucleotide sequence showed a 2,712-base-pair open reading frame; the predicted molecular mass of the deduced protein is 103 kilodaltons. Deletion mutants of the open reading frame were constructed and genetically characterized. The deduced amino acid sequence of the PMS1 gene exhibited homology to those of the mutL gene from Salmonella typhimurium and the hexB gene from Streptococcus pneumoniae, genes required for DNA mismatch repair in these organisms. The homology suggests an evolutionary relationship of DNA mismatch repair in procaryotes and eucaryotes.
摘要
酿酒酵母的PMS1基因与酵母细胞中的DNA错配修复有关（M. S. 威廉姆森、J. C. 盖姆和S. 福格尔，《遗传学》110:609 - 646，1985），该基因被克隆并测定了核苷酸序列。核苷酸序列显示有一个2712个碱基对的开放阅读框；推导蛋白质的预测分子量为103千道尔顿。构建了开放阅读框的缺失突变体并进行了遗传学特征分析。PMS1基因推导的氨基酸序列与鼠伤寒沙门氏菌的mutL基因和肺炎链球菌的hexB基因的氨基酸序列具有同源性，这些基因是这些生物体中DNA错配修复所必需的。这种同源性表明原核生物和真核生物中DNA错配修复存在进化关系。
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