Chang Lei, Lan Tian, Wu Long, Li Cuicui, Yuan Yufeng, Liu Zhisu
Department of General Surgery, Research Center of Digestive Diseases, Zhongnan Hospital of Wuhan University Wuhan 430071, P. R. China.
Int J Clin Exp Med. 2015 Oct 15;8(10):17036-45. eCollection 2015.
A quantity of case-control studies have been performed to address the association between the three interleukin-6 (IL-6) polymorphisms (-572G/C, -597G/A and -174G/C) and the risk of HBV related liver diseases. However, previous research results are inconsistent. We conducted this meta-analysis to clarify the correlation between these IL-6 polymorphisms and HBV related liver diseases.
We searched in PubMed, EMBASE, Cochrane Library as well as Chinese databases including China National Knowledge Infrastructure (CNKI) and WanFang database for all the relevant studies up to April 15, 2015. The data were extracted by two independent authors. Odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated.
A total of 10 studies consisting of 3879 cases and 2812 controls were included in this metaanalysis. For IL-6 polymorphism -572G/C, an association with increased chronic hepatitis B (CHB) risk was observed under in allelic, homozygous, heterozygous, dominant and recessive model. However, IL-6 polymorphisms (-572G/C) were not related to Inactive Carrier (IC), Liver Cirrhosis (LC) and Hepatocellular Carcinoma (HCC) risk in this study. We also found that IL-6 polymorphisms (-597G/A) were related to CHB in allelic, heterozygous, recessive model. For IL-6 polymorphism -174G/C, we did not find any association with CHB risk.
The present meta-analysis indicated that IL-6 polymorphisms -572G/C and -597G/A significantly associate with CHB risk, but might not be significantly related to the progressive HBV such as LC and HCC. IL-6 polymorphisms -174G/C might not significantly associate with HBV related liver diseases.
已开展了大量病例对照研究，以探讨三种白细胞介素-6（IL-6）基因多态性（-572G/C、-597G/A和-174G/C）与乙肝相关肝病风险之间的关联。然而，既往研究结果并不一致。我们进行此项荟萃分析，以阐明这些IL-6基因多态性与乙肝相关肝病之间的相关性。
我们检索了PubMed、EMBASE、Cochrane图书馆以及包括中国知网（CNKI）和万方数据库在内的中文数据库，以获取截至2015年4月15日的所有相关研究。数据由两位独立作者提取。计算比值比（OR）和95%置信区间（95%CI）。
本荟萃分析共纳入10项研究，包括3879例病例和2812例对照。对于IL-6基因多态性-572G/C，在等位基因、纯合子、杂合子、显性和隐性模型下，观察到与慢性乙型肝炎（CHB）风险增加相关。然而，在本研究中，IL-6基因多态性（-572G/C）与非活动性携带者（IC）、肝硬化（LC）和肝细胞癌（HCC）风险无关。我们还发现，IL-6基因多态性（-597G/A）在等位基因、杂合子、隐性模型下与CHB相关。对于IL-6基因多态性-174G/C，我们未发现其与CHB风险有任何关联。
本荟萃分析表明，IL-6基因多态性-572G/C和-597G/A与CHB风险显著相关，但可能与诸如LC和HCC等进展性乙肝无显著关联。IL-6基因多态性-174G/C可能与乙肝相关肝病无显著关联。
