Department of General Surgery, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430071, China.
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430071, China.
Dis Markers. 2013;35(6):799-805. doi: 10.1155/2013/508023. Epub 2013 Nov 25.
Interleukin-6 plays an important role in chronic inflammation as well as tumor growth and progression. Here, a case-control study was undertaken to investigate the association of rs1800796 polymorphism of IL-6 gene and serum levels with disease progression of chronic HBV infection. Rs1800796 polymorphism was genotyped in 641 Chinese Han patients with chronic HBV infection, including 23 IT, 25 IC, 292 CHB, 153 LC, and 148 HCC patients and 265 healthy controls. Serum IL-6 levels were measured in 23 IT, 25 IC, 47 CHB, 41 LC, and 49 HCC patients and 45 healthy controls, and the classifications of HCC were accorded to BCLC staging system. We found no significant association between rs1800796 polymorphism and disease progression of chronic HBV infection; however, serum IL-6 levels showed significant statistical differences between patients with CHB, LC, and HCC. Moreover, statistical differences can be observed in patients with terminal stage HCC compared with those of early to intermediate or advanced stage HCC. Our findings suggest that rs1800796 polymorphism unlikely contribute significantly to affect the progression of chronic HBV infection, and serum IL-6 levels can act as a useful indicator for disease progression and severity of chronic HBV infection.
白细胞介素-6 在慢性炎症以及肿瘤生长和进展中发挥着重要作用。在这里，我们进行了一项病例对照研究，旨在探讨白细胞介素-6 基因 rs1800796 多态性与慢性乙型肝炎病毒感染疾病进展之间的关联。在 641 例中国汉族慢性乙型肝炎病毒感染患者中，包括 23 例 IT、25 例 IC、292 例 CHB、153 例 LC 和 148 例 HCC 患者和 265 例健康对照者，对 rs1800796 多态性进行了基因分型。我们检测了 23 例 IT、25 例 IC、47 例 CHB、41 例 LC 和 49 例 HCC 患者以及 45 例健康对照者的血清白细胞介素-6 水平，并且根据巴塞罗那临床肝癌分期系统对 HCC 进行了分类。我们发现 rs1800796 多态性与慢性乙型肝炎病毒感染的疾病进展之间没有显著关联；然而，CHB、LC 和 HCC 患者之间的血清白细胞介素-6 水平存在显著的统计学差异。此外，与早期至中期或晚期 HCC 患者相比，终末期 HCC 患者之间也可以观察到统计学差异。我们的研究结果表明，rs1800796 多态性不太可能显著影响慢性乙型肝炎病毒感染的进展，而血清白细胞介素-6 水平可以作为疾病进展和慢性乙型肝炎病毒感染严重程度的有用指标。
