Du Guangyuan, Liu Chuan, Yu Wenbin, Li Juan, Li Wei, Wang Chengyuan, Zhu Jiang
Department of Otolaryngology, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China.
Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Head and Neck surgery, Peking University Cancer Hospital and Institute Beijing 100142, China.
Int J Clin Exp Med. 2015 Oct 15;8(10):17206-13. eCollection 2015.
Radiotherapy and laser resection are established treatment modalities for early glottic carcinoma. To date, there is no confirmed conclusion which treatment is better for early glottic cancer. The objective of this study was to conduct a meta-analysis to compare the voice outcomes after laser resection (LS) and radiotherapy (RT) of Tis-T1N0M0 glottic carcinoma.
we searched the relevant electronic studies and performed a meta-analysis based on 13 published studies. The Chi-square based I(2)-statistic test was performed to evaluate possible heterogeneity across the studies. Additionally, random-effects models were used to calculate mean differences with 95% confidence intervals (CIs).
Overall, a total of 13 published studies were included in our study, with 368 patients in the RT group and 440 patients in the LS group, respectively. No significant differences in Voice Handicap Index (VHI), jitter and shimmer were found between RT and endoscopic LS among patients with Tis-T1N0M0 glottic carcinoma and T1aN0M0 laryngeal cancer. However, the acoustic voice analysis parameters of Fo values were significantly lower in RT group than that in LS group.
The results from this meta-analysis support that the LS has more advantages than RT in terms of voice quality. However, more studies on voice outcome need to validate our findings.
放射治疗和激光切除术是早期声门癌的既定治疗方式。迄今为止，对于早期声门癌哪种治疗方法更好尚无定论。本研究的目的是进行一项荟萃分析，以比较Tis-T1N0M0声门癌激光切除术（LS）和放射治疗（RT）后的嗓音结果。
我们检索了相关电子研究，并基于13项已发表的研究进行了荟萃分析。使用基于卡方的I(2)统计检验来评估各研究之间可能存在的异质性。此外，采用随机效应模型计算平均差异及95%置信区间（CI）。
总体而言，我们的研究共纳入13项已发表的研究，放疗组有368例患者，激光切除组有440例患者。在Tis-T1N0M0声门癌和T1aN0M0喉癌患者中，放疗与内镜下激光切除术后的嗓音障碍指数（VHI）、抖动和闪烁度均无显著差异。然而，放疗组的声学嗓音分析参数基频（Fo）值显著低于激光切除组。
该荟萃分析结果支持激光切除术在嗓音质量方面比放射治疗更具优势。然而，需要更多关于嗓音结果的研究来验证我们的发现。
