Zhang Peng, Zhang Youzhi, Yang Haihua, Li Wenjing, Chen Xiaodong, Long Feng
Department of Respiratory Medicine, Huashan Hospital North, Fudan University Shanghai 201907, China.
Int J Clin Exp Med. 2015 Oct 15;8(10):17941-9. eCollection 2015.
Microsomal epoxide hydrolase 1 (EPHX1) may play an important role in epigenetic change and DNA repair concerned with lung cancer. Several studies have investigated the association between EPHX1 rs1051740 and lung cancer risk, but there is no consensus. Therefore, we performed a meta-analysis to further identify the relationship.
The Pubmed and Embase databases were searched for eligible studies. An odds ratio (OR) with 95% confidence intervals (CIs) was used to assess the correlation between EPHX1 rs1051740 polymorphism and lung cancer risk through a meta-analysis.
Overall, no significant relationship was found between EPHX1 rs1051740 and lung cancer risk (CC vs. TT: OR=1.10, 95% CI=0.88-1.36; CC+CT vs. TT: OR=1.02, 95% CI=0.88-1.18; CC vs. TT+CT: OR=1.08, 95% CI=0.91-1.27; C vs. T: OR=1.04, 95% CI=0.93-1.17; CT vs. TT: OR=0.98, 95% CI=0.85-1.13). Nevertheless, further subgroup analysis by ethnicity demonstrated that EPHX1 rs1051740 with CC genotype or C allele was an increased risk for lung cancer in Asians (CC vs. TT: OR=1.54, 95% CI=1.23-1.94; CC vs. TT+CT: OR=1.43, 95% CI=1.20-1.71; C vs. T: OR=1.26, 95% CI=1.08-1.47).
This meta-analysis indicates that EPHX1 rs1051740 with CC genotype or C allele may be a risk factor in Asians.
微粒体环氧化物水解酶1（EPHX1）可能在与肺癌相关的表观遗传变化和DNA修复中发挥重要作用。多项研究调查了EPHX1 rs1051740与肺癌风险之间的关联，但尚未达成共识。因此，我们进行了一项荟萃分析以进一步确定两者之间的关系。
检索PubMed和Embase数据库以查找符合条件的研究。通过荟萃分析，使用比值比（OR）及其95%置信区间（CI）来评估EPHX1 rs1051740多态性与肺癌风险之间的相关性。
总体而言，未发现EPHX1 rs1051740与肺癌风险之间存在显著关系（CC与TT比较：OR = 1.10，95% CI = 0.88 - 1.36；CC + CT与TT比较：OR = 1.02，95% CI = 0.88 - 1.18；CC与TT + CT比较：OR = 1.08，95% CI = 0.91 - 1.27；C与T比较：OR = 1.04，95% CI = 0.93 - 1.17；CT与TT比较：OR = 0.98，95% CI = 0.85 - 1.13）。然而，按种族进行的进一步亚组分析表明，具有CC基因型或C等位基因的EPHX1 rs1051740在亚洲人中会增加患肺癌的风险（CC与TT比较：OR = 1.54，95% CI = 1.23 - 1.94；CC与TT + CT比较：OR = 1.43，95% CI = 1.20 - 1.71；C与T比较：OR = 1.26，95% CI = 1.08 - 1.47）。
这项荟萃分析表明，具有CC基因型或C等位基因的EPHX1 rs1051740可能是亚洲人的一个风险因素。
