a Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University , Beijing , China.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):2338-2342. doi: 10.1080/21691401.2019.1622551.
We carried out a meta-analysis of case-control studies to determine whether epoxide hydrolase 1 () gene polymorphism rs1051740 was related to the risk of ovarian cancer. Electronic databases were searched for relevant articles published in English or Chinese language. We calculated crude odds ratios (ORs) with their 95% confidence intervals (95% CIs) to assess the relationship of polymorphism rs1051740 with ovarian cancer risk. In addition, subgroup analyses were also conducted based on ethnicity and control source. Between-study heterogeneity was inspected with test and statistic. Five eligible studies with a total of 1919 ovarian cancer patients and 1829 controls were ultimately included in the present meta-analysis. Overall results demonstrated that the association between polymorphism rs1051740 and ovarian cancer risk had no statistical significance either in total analysis or in subgroup analyses by ethnicity and source of control. polymorphism rs1051740 may have no independent effect on ovarian cancer susceptibility.
我们进行了一项病例对照研究的荟萃分析，以确定环氧化物水解酶 1（）基因多态性 rs1051740 是否与卵巢癌的风险相关。检索了英文和中文文献的电子数据库，以获取相关文章。我们计算了粗比值比（OR）及其 95%置信区间（95%CI），以评估 多态性 rs1051740 与卵巢癌风险的关系。此外，还根据种族和对照来源进行了亚组分析。用 检验和 统计检验来检测组间异质性。最终纳入了五项符合条件的研究，共包括 1919 名卵巢癌患者和 1829 名对照。总体结果表明，在总分析或按种族和对照来源进行的亚组分析中，多态性 rs1051740 与卵巢癌风险之间均无统计学意义。多态性 rs1051740 可能对卵巢癌易感性没有独立影响。
