Zhao Ge, Liu Jing, Meng Tao
Department of Obstetrics, The First Affiliated Hospital of China Medical University, Shenyang, China.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):5526-5538. doi: 10.1080/14767058.2021.1887123. Epub 2021 Feb 15.
Previous studies have detected the association of polymorphisms in oxidative stress-related genes and with pre-eclampsia (PE) risk, but the results are inconsistent among studies. Thus, a meta-analysis was performed to obtain more conclusive results.
Eligible studies were retrieved in PubMed, Web of Science, EMBASE, Scopus, and CNKI. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to evaluate the relationship between rs1051740, rs2234922, rs4880 polymorphisms, and PE susceptibility in the genetic models. The subgroup analysis was also performed.
Fourteen studies with a total of 4250 participants were included, including 1784 PE patients and 2466 healthy women. There was a statistically significant association between rs1051740 polymorphism and PE in Caucasians within the allele, dominant, heterozygous, and homozygous models (OR = 0.79, 95% CI = 0.64-0.98; OR = 0.64, 95% CI = 0.47-0.87; OR = 0.61, 95% CI = 0.44-0.85; OR = 0.63, 95% CI = 0.42-0.97, respectively). There was a statistically significant association between rs2234922 polymorphism and PE in Middle Easterners within the recessive and homozygous models (OR = 3.59, 95% CI = 1.25-10.32; OR = 3.99, 95% CI = 1.38-11.49, respectively). There was no statistically significant association between rs4880 polymorphism and PE within five genetic models. Subgroup analysis didn't reveal any association between rs4880 polymorphism and PE in Asians, Caucasians, or Middle Easterners.
This meta-analysis shows a significant association between the rs1051740 and PE risk in Caucasians. Meantime, there was a statistically significant association between rs2234922 polymorphism and PE in Middle Easterners.
既往研究已检测到氧化应激相关基因多态性与子痫前期（PE）风险之间的关联，但研究结果并不一致。因此，进行了一项荟萃分析以获得更具结论性的结果。
在PubMed、Web of Science、EMBASE、Scopus和中国知网中检索符合条件的研究。采用比值比（OR）及95%置信区间（CI）评估rs1051740、rs2234922、rs4880多态性与遗传模型中PE易感性之间的关系。还进行了亚组分析。
纳入14项研究，共4250名参与者，其中包括1784例PE患者和2466名健康女性。在等位基因、显性、杂合子和纯合子模型中，rs1051740多态性与白种人中的PE存在统计学显著关联（OR分别为0.79，95%CI = 0.64 - 0.98；OR = 0.64，95%CI = 0.47 - 0.87；OR = 0.61，95%CI = 0.44 - 0.85；OR = 0.63，95%CI = 0.42 - 0.97）。在隐性和纯合子模型中，rs2234922多态性与中东人中的PE存在统计学显著关联（OR分别为3.59，95%CI = 1.25 - 10.32；OR = 3.99，95%CI = 1.38 - 11.49）。在五种遗传模型中，rs4880多态性与PE之间无统计学显著关联。亚组分析未显示rs4880多态性与亚洲人、白种人或中东人中的PE之间存在任何关联。
这项荟萃分析显示白种人中rs1051740与PE风险之间存在显著关联。同时，中东人中rs2234922多态性与PE之间存在统计学显著关联。
