Nobile Maria, Cataldo Maria Giulia, Giorda Roberto, Battaglia Marco, Baschirotto Cinzia, Bellina Monica, Marino Cecilia, Molteni Massimo
Child Psychiatry Unit, Eugenio Medea Scientific Institute, Bosisio, Parini, Italy.
Biol Psychiatry. 2004 Aug 15;56(4):292-5. doi: 10.1016/j.biopsych.2004.05.018.
Pediatric depression can be particularly informative for clarification of the causes of mood disorders. The aim of this work was to explore the possible association between childhood- and early-adolescent-onset DSM-IV depressive disorders (DD; including major depression and dysthymia) and the serotonin transporter-linked promoter polymorphism (5-HTTLPR) locus.
The case-control sample consisted of 68 unrelated patients with DD, and 68 unrelated age- and gender-matched healthy control subjects. The same patients were included in the family-based study, which consisted of 41 triads and 11 dyads.
An excess of the SS-genotype (p =.025) and of the S-allele (p =.021) was found among DD children (odds ratio = 1.81; 95% confidence interval = 1.12-2.94). The family-based results suggested that the S-allele was preferentially transmitted to depressed children (haplotype-based haplotype relative risk: chi(2) = 7.231 df = 1, p =.007; transmission disequilibrium test: chi(2) = 5.233, df = 1, p =.022).
A role for the 5-HTTLPR locus that needs replication in larger samples is suggested in childhood DD.
儿童期抑郁症对于阐明情绪障碍的病因可能具有特别重要的意义。本研究的目的是探讨儿童期和青少年早期起病的DSM-IV抑郁症（DD；包括重度抑郁症和心境恶劣）与5-羟色胺转运体相关启动子多态性（5-HTTLPR）位点之间可能存在的关联。
病例对照样本包括68例无亲缘关系的DD患者以及68例年龄和性别匹配的无亲缘关系健康对照者。同样的患者被纳入基于家系的研究，该研究由41个三联体和11个二联体组成。
在患DD的儿童中发现SS基因型（p = 0.025）和S等位基因（p = 0.021）的比例过高（优势比 = 1.81；95%置信区间 = 1.12 - 2.94）。基于家系的研究结果表明，S等位基因优先传递给患抑郁症的儿童（基于单倍型的单倍型相对风险：χ² = 7.231，自由度 = 1，p = 0.007；传递不平衡检验：χ² = 5.233，自由度 = 1，p = 0.022）。
提示5-HTTLPR位点在儿童期DD中起一定作用，但需要在更大样本中进行重复验证。
