在来曲唑刺激方案的子宫内膜准备中，用于触发卵母细胞的促性腺激素释放激素激动剂不影响冻融胚胎移植的临床结局。
Gonadotropin-releasing hormone agonist for oocyte triggering in endometrial preparation of letrozole stimulation protocols does not affect clinical outcome of frozen-thawed embryo transfer.
作者信息
Huang Pin-Xiu, Wei Ji-Hong, Wei Li-Hong
机构信息
Department of Reproductive Medicine, Liuzhou Maternity and Child Healthcare Hospital Guangxi Province, 545001, China.
出版信息
Int J Clin Exp Med. 2015 Oct 15;8(10):19072-8. eCollection 2015.
Abstract
OBJECTIVE
This study aims to evaluate the effectiveness of GnRH agonist in comparison with hCG for triggering final oocyte maturation in endometrial preparation of letrozole stimulation protocols for frozen-thawed embryo transfer.
METHODS
The frozen-thawed embryo transfer cycles (FET) that use the letrozole stimulation protocols for endometrial preparation were divided into two groups according the different method of triggering final oocyte maturation. The serum LH and E2 levels, and the endometrial thickness on the day of triggering, the clinical pregnancy rates, the miscarriage rates and live birth rates were compared.
RESULTS
There were no significant differences in the age, the endometrial thickness, the number of embryos transferred between the two groups. The clinical pregnancy rate, abortion rate and live birth rates of the group A were similar compared with the group B, P<0.05.
CONCLUSION
Using GnRH agonist for oocyte triggering in endometrial preparation of letrozole stimulation protocols for frozen-thawed embryo transfer does not affect the clinical outcome compared with hCG under the same luteal phase support.
摘要
目的
本研究旨在比较促性腺激素释放激素（GnRH）激动剂与人类绒毛膜促性腺激素（hCG）在来曲唑刺激方案子宫内膜准备用于冻融胚胎移植中触发最终卵母细胞成熟的有效性。
方法
将采用来曲唑刺激方案进行子宫内膜准备的冻融胚胎移植周期（FET），根据触发最终卵母细胞成熟的不同方法分为两组。比较触发日的血清促黄体生成素（LH）和雌二醇（E2）水平、子宫内膜厚度、临床妊娠率、流产率和活产率。
结果
两组在年龄、子宫内膜厚度、移植胚胎数量方面无显著差异。A组的临床妊娠率、流产率和活产率与B组相似，P<0.05。
结论
在相同的黄体期支持下，在来曲唑刺激方案子宫内膜准备用于冻融胚胎移植中使用GnRH激动剂触发卵母细胞成熟与hCG相比不影响临床结局。
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