Wang Xuhong, Zhang Ning, Yu Caiguo, Ji Zhili
Beijing Key Laboratory of Diabetes Prevention and ResearchBeijing, China; Department of Endocrinology, Beijing Lu He Hospital, Capital Medical UniversityChina.
Department of General Surgery, Beijing Lu He Hospital, Capital Medical University China.
Int J Clin Exp Med. 2015 Oct 15;8(10):19107-13. eCollection 2015.
To evaluate whether neck circumference (NC) could be used as a valid and effective method for identifying obesity and insulin resistance (IR) in Chinese adults.
A total of 3307 adults aged 20-65 years were randomly recruited from two communities of Tongzhou, Beijing. Height, weight, waist circumference (WC), hip circumference (HC), neck circumference (NC), blood pressure, fasting plasma glucose (FPG), fasting serum insulin (FINS), total cholesterol (TC), serum triglyceride (TG), High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and Urinary albumin (UAlb) were measured. Pearson correlation coefficient was used to explore the relationship between NC and other measurements. Furthermore, the best cutoff values of NC for central obesity identification were determined by applying the receiver operating characteristic (ROC) curve analysis.
NC correlated positively with BMI, SBP and WC In both sexes. Both WC and NC correlated significantly positively with IR. A positive correlation between NC and FPG as well as a negative correlation between NC and HDL were found in obese men. NC≥38.5 cm for men and ≥34.5 cm for women were determined to be the best cutoff levels for identifying subjects with central obesity, with 82.9% accuracy for men and 79.9% accuracy for women.
NC correlated positively with BMI and WC in both genders, indicating that NC could be used as a valid marker for both overall obesity and central obesity. In addition, measuring NC was shown to be a useful test for IR identification. Large number of NC is suggested to be associated with high risk of developing metabolic disorders, such as diabetes and dyslipidemia.
评估颈围（NC）能否作为识别中国成年人肥胖和胰岛素抵抗（IR）的有效方法。
从北京通州的两个社区随机招募了3307名年龄在20 - 65岁之间的成年人。测量身高、体重、腰围（WC）、臀围（HC）、颈围（NC）、血压、空腹血糖（FPG）、空腹血清胰岛素（FINS）、总胆固醇（TC）、血清甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和尿白蛋白（UAlb）。采用Pearson相关系数探讨NC与其他测量指标之间的关系。此外，通过应用受试者工作特征（ROC）曲线分析确定NC用于识别中心性肥胖的最佳截断值。
在男女两性中，NC均与BMI、收缩压（SBP）和WC呈正相关。WC和NC均与IR显著正相关。在肥胖男性中，发现NC与FPG呈正相关，与HDL呈负相关。男性NC≥38.5 cm、女性NC≥34.5 cm被确定为识别中心性肥胖受试者的最佳截断水平，男性的准确率为82.9%，女性为79.9%。
NC在男女两性中均与BMI和WC呈正相关，表明NC可作为总体肥胖和中心性肥胖的有效标志物。此外，测量NC被证明是一种识别IR的有用检测方法。大量的NC被认为与发生代谢紊乱如糖尿病和血脂异常的高风险相关。
