Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, 74th Zhongshan Road II, Guangzhou 510080, People's Republic of China.
Cardiovasc Diabetol. 2013 May 16;12:76. doi: 10.1186/1475-2840-12-76.
The predictive potentials of neck circumference (NC) for cardio-metabolic risks remain uncertain. The aim of this study was to investigate whether NC independently contributes to the prediction of cardio-metabolic risks beyond body mass index (BMI), waist circumference (WC) and waist to hip ratio (WHpR) in a large Chinese population.
A total of 4201 participants (2508 men and 1693 women) aged 20-85 were recruited from the Health Examination Centre between May 2009 and April 2010, anthropometric indices, biochemical and clinical parameters were measured. Receiver operating characteristic, partial correlation and logistic regression analyses were employed to evaluate the association of the anthropometric indices to cardio-metabolic risks separately by gender.
Neck circumference was positively correlated with SBP and DBP (r=0.250 and 0.261), fasting blood glucose (FBP) (r=0.177), TG (r=0.240), TC (r=0.143) and LDL-C (r=0.088) and negatively correlated with HDL-C (r=-0.202) in males (all P<0.01). Similar results were found in females with the exception of TC. The AUCs of NC for metabolic abnormalities ranged from 0.558 (Increased LDL-C) to 0.683 (MS-rf) in men and 0.596 (Increased LDL-C) to 0.703 (MS-rf) in women (P<0.01). The NC of ≥37 cm for men and ≥33 cm for women were the best cut-off points for metabolic syndrome. The adjusted ORs (95% CIs) of NC in men and women respectively were 1.29 (1.12-1.48) and 1.44 (1.20-1.72) for metabolic syndrome risk factors (MS-rf), 1.15 (1.01-1.32) and 1.22 (1.03-1.46) for high BP, 1.16 (1.02-1.33) and 1.42 (1.18-1.71) for increased TG, and 1.26 (1.06-1.50) and 1.32 (1.06-1.65) for increased FBP; the adjusted OR of NC in women for decreased HDL-C was 1.29 (1.10-1.51).
Neck circumference was significantly associated with cardio-metabolic risk factors and independently contributed to the prediction of cardio-metabolic risks beyond the classical anthropometric indices in adults of China.
颈围（NC）对心血管代谢风险的预测潜力仍不确定。本研究的目的是在 20-85 岁的中国成年人中，调查颈围是否独立于体重指数（BMI）、腰围（WC）和腰臀比（WHpR）之外，对心血管代谢风险有预测作用。
2009 年 5 月至 2010 年 4 月期间，从健康体检中心招募了 4201 名参与者（男性 2508 名，女性 1693 名），测量了人体测量指数、生化和临床参数。采用受试者工作特征、偏相关和逻辑回归分析分别评估男性和女性的人体测量指数与心血管代谢风险之间的关联。
颈围与收缩压和舒张压（r=0.250 和 0.261）、空腹血糖（FBP）（r=0.177）、甘油三酯（TG）（r=0.240）、总胆固醇（TC）（r=0.143）和低密度脂蛋白胆固醇（LDL-C）（r=0.088）呈正相关，与高密度脂蛋白胆固醇（HDL-C）（r=-0.202）呈负相关（均 P<0.01）。在女性中也发现了类似的结果，但 TC 除外。男性颈围对代谢异常的 AUC 范围为 0.558（升高的 LDL-C）至 0.683（MS-rf），女性为 0.596（升高的 LDL-C）至 0.703（MS-rf）（均 P<0.01）。男性颈围≥37cm，女性颈围≥33cm 是代谢综合征的最佳截断点。男性和女性颈围的调整后 OR（95%CI）分别为代谢综合征危险因素（MS-rf）的 1.29（1.12-1.48）和 1.44（1.20-1.72），高血压的 1.15（1.01-1.32）和 1.22（1.03-1.46），TG 升高的 1.16（1.02-1.33）和 1.42（1.18-1.71），FBP 升高的 1.26（1.06-1.50）和 1.32（1.06-1.65），女性 HDL-C 降低的调整后 OR 为 1.29（1.10-1.51）。
颈围与心血管代谢危险因素显著相关，并独立于中国成年人的经典人体测量指数，对心血管代谢风险有预测作用。
