Collins Tracie C, Twumasi-Ankrah Philip
Department of Preventive Medicine and Public Health, School of Medicine, The University of Kansas, Wichita, KS, USA.
SAGE Open Med. 2013 Sep 24;1:2050312113505559. doi: 10.1177/2050312113505559. eCollection 2013.
In this pilot study, we sought to determine whether walking reduces inflammation in patients with diabetes mellitus and peripheral arterial/artery disease.
We obtained blood samples from patients with diabetes mellitus and peripheral arterial/artery disease. Intervention participants were advised to walk for 50 min 3 days per week for 6 months. Participants completed assessments of comorbidities and walking ability. Difference-in-difference analyses were used to assess the relationship between group assignment and each biomarker over time.
We randomized 55 participants (control = 25 and intervention = 30). At 6 months and based on p values of <0.20, vascular cellular adhesion molecule, beta-2 microglobulin, total cholesterol, and triglycerides demonstrated a greater decrease among participants randomized to the intervention compared to the control.
Walking may reduce inflammation in persons with diabetes mellitus and peripheral arterial/artery disease. Further research is needed to determine the impact of walking on inflammation in persons with vascular disease.
在这项试点研究中，我们试图确定步行是否能减轻糖尿病合并外周动脉疾病患者的炎症反应。
我们采集了糖尿病合并外周动脉疾病患者的血样。干预组参与者被建议每周3天、每次步行50分钟，持续6个月。参与者完成了合并症和步行能力评估。采用差值法分析来评估分组与各生物标志物随时间的关系。
我们将55名参与者随机分组（对照组 = 25人，干预组 = 30人）。在6个月时，基于p值<0.20，与对照组相比，随机分配到干预组的参与者的血管细胞黏附分子、β2微球蛋白、总胆固醇和甘油三酯水平下降幅度更大。
步行可能减轻糖尿病合并外周动脉疾病患者的炎症反应。需要进一步研究以确定步行对血管疾病患者炎症的影响。
