Coghill Nikki, Cooper Ashley R
Faculty of Health & Life Sciences, University of the West of England, UK.
Prev Med. 2008 Jun;46(6):545-51. doi: 10.1016/j.ypmed.2008.01.002. Epub 2008 Jan 16.
Hypercholesterolaemia and physical inactivity significantly contribute towards risk of coronary heart disease. Increased physical activity may be an effective way to improve lipid profiles in hypercholesterolaemic individuals. The aim of this study was to investigate whether a home-based physical activity program meeting current guidelines improved the lipid profile of hypercholesterolaemic men.
Sixty-seven hypercholesterolaemic men (55.1 (4.9) years), from Bristol England, recruited between 2002-2004, were randomized to either 12 weeks of brisk walking sufficient to expend at least 300 kcal each walk or control condition. Fasting lipids including total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), glucose, insulin, blood pressure and anthropometric characteristics were measured at baseline and follow-up. Compliance was monitored using accelerometers and activity logs.
After controlling for baseline differences, TC/HDL-C was significantly lower in the intervention group at follow-up (-0.28, 95% CI: -0.52, -0.03, p=0.03). An increase in HDL-C (0.07 mmol/l: -0.01, 0.12, p=0.07) and reduction in TG (-0.30 mmol/l: -0.64, 0.03, p=0.07) in intervention participants were of borderline statistical significance. Weight significantly decreased in intervention participants (-1.40 kg: -2.43, -0.38, p<0.01). No other significant between group effects were found. Compliance to the walking program was 97.6%.
Twelve weeks of moderate intensity walking was sufficient to improve TC/HDL-C in hypercholesterolaemic men, primarily through improvement in HDL-C.
高胆固醇血症和缺乏身体活动是冠心病风险的重要因素。增加身体活动可能是改善高胆固醇血症患者血脂谱的有效方法。本研究旨在调查一项符合当前指南的居家身体活动计划是否能改善高胆固醇血症男性的血脂谱。
2002年至2004年间，从英国布里斯托尔招募了67名高胆固醇血症男性（年龄55.1（4.9）岁），随机分为两组，一组进行为期12周的快走，每次快走消耗至少300千卡热量，另一组为对照组。在基线和随访时测量空腹血脂，包括总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、血糖、胰岛素、血压和人体测量特征。使用加速度计和活动日志监测依从性。
在控制基线差异后，干预组随访时的TC/HDL-C显著降低（-0.28，95%CI：-0.52，-0.03，p=0.03）。干预组参与者的HDL-C升高（0.07 mmol/l：-0.01，0.12，p=0.07）和TG降低（-0.30 mmol/l：-0.64，0.03，p=0.07）具有边缘统计学意义。干预组参与者的体重显著下降（-1.40 kg：-2.43，-0.38，p<0.01）。未发现其他显著的组间效应。步行计划的依从率为97.6%。
为期12周的中等强度步行足以改善高胆固醇血症男性的TC/HDL-C，主要是通过提高HDL-C实现的。
