Harlev Avi, Agarwal Ashok, Gunes Sezgin Ozgur, Shetty Amit, du Plessis Stefan Simon
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.; Fertility and In Vitro Fertilization Unit, Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheba, Israel.
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
World J Mens Health. 2015 Dec;33(3):143-60. doi: 10.5534/wjmh.2015.33.3.143. Epub 2015 Dec 23.
Many studies have reported that the contents of cigarette smoke negatively affect sperm parameters, seminal plasma, and various other fertility factors. Nevertheless, the actual effect of smoking on male fertility is not clear. The effect of smoking on semen parameters is based on the well-established biological finding that smoking increases the presence of reactive oxygen species, thereby resulting in oxidative stress (OS). OS has devastating effects on sperm parameters, such as viability and morphology, and impairs sperm function, hence reducing male fertility. However, not all studies have come to the same conclusions. This review sheds light upon the arguable association between smoking and male fertility and also assesses the impact of non-smoking routes of tobacco consumption on male infertility. It also highlights the evidence that links smoking with male infertility, including newly emerging genetic and epigenetic data, and discusses the clinical implications thereof.
许多研究报告称，香烟烟雾中的成分会对精子参数、精浆及其他多种生育因素产生负面影响。然而，吸烟对男性生育能力的实际影响尚不清楚。吸烟对精液参数的影响基于一个已得到充分证实的生物学发现，即吸烟会增加活性氧的含量，从而导致氧化应激（OS）。氧化应激对精子参数（如活力和形态）具有毁灭性影响，并损害精子功能，进而降低男性生育能力。然而，并非所有研究都得出了相同的结论。本综述阐明了吸烟与男性生育能力之间存在争议的关联，还评估了非吸烟途径的烟草消费对男性不育的影响。它还强调了将吸烟与男性不育联系起来的证据，包括新出现的基因和表观遗传数据，并讨论了其临床意义。
