Knutsen A P
Department of Pediatrics, St. Louis University Medical Center, Mo 63104.
J Allergy Clin Immunol. 1989 Oct;84(4 Pt 2):640-5; discussion 645-7. doi: 10.1016/0091-6749(89)90203-0.
Selective IgG subclass deficiencies and/or selectively impaired antibody responses to bacterial capsular polysaccharide antigens have been increasingly reported. In this report, 13 children with recurrent infections and deficient antibody responses to polysaccharide antigens are described. Serum IgG2 subclass concentrations were normal in all the patients, and two children had low IgG3 levels. Mean serum antibody concentrations to the capsular polysaccharide antigens of Streptococcus pneumoniae and Haemophilus influenzae were significantly decreased after immunizations, but antibody responses to diphtheria and tetanus toxoids were normal. The identification of children with selective antibody deficiencies and recurrent infections has prompted a multicenter, double-blind, placebo-controlled study to evaluate the efficacy and safety of intravenous immune globulin therapy in these patients.
选择性IgG亚类缺陷和/或对细菌荚膜多糖抗原的抗体反应选择性受损的报道日益增多。在本报告中，描述了13例反复感染且对多糖抗原抗体反应缺陷的儿童。所有患者的血清IgG2亚类浓度均正常，2例儿童IgG3水平较低。免疫接种后，肺炎链球菌和流感嗜血杆菌荚膜多糖抗原的平均血清抗体浓度显著降低，但对白喉和破伤风类毒素的抗体反应正常。对选择性抗体缺陷和反复感染儿童的识别促使开展了一项多中心、双盲、安慰剂对照研究，以评估静脉注射免疫球蛋白治疗这些患者的疗效和安全性。
