Jefferis R, Kumararatne D S
Division of Immunology, University of Birmingham Medical School, England, UK.
Clin Exp Immunol. 1990 Sep;81(3):357-67. doi: 10.1111/j.1365-2249.1990.tb05339.x.
Each of the four human IgG subclasses exhibits a unique profile of effector functions relevant to the clearance and elimination of infecting microorganisms. The quantitative response within each IgG subclass varies with the nature of the antigen, its route of entry and, presumably, the form in which it is presented to the immune system. This results in antibody responses to certain antigens being predominantly or exclusively of a single IgG subclass. An inability to produce antibody of the optimally protective isotype can result in a selective immunodeficiency state. This is particularly apparent for responses to certain bacterial carbohydrate antigens that are normally of IgG2 isotype. A failure to produce the appropriate specific antibody response may result in recurrent upper and/or lower respiratory tract infection. Careful patient investigation can identify such deficiencies and suggest appropriate clinical management. In this review we outline the biology and clinical relevance of the IgG subclasses and summarize current rational treatment approaches.
人类四种IgG亚类中的每一种都表现出与感染微生物的清除和消除相关的独特效应功能谱。每个IgG亚类中的定量反应随抗原的性质、其进入途径以及大概其呈现给免疫系统的形式而变化。这导致对某些抗原的抗体反应主要或完全是单一的IgG亚类。无法产生具有最佳保护作用的同种型抗体可导致选择性免疫缺陷状态。这在对某些通常为IgG2同种型的细菌碳水化合物抗原的反应中尤为明显。未能产生适当的特异性抗体反应可能导致反复的上呼吸道和/或下呼吸道感染。仔细的患者调查可以识别此类缺陷并提出适当的临床管理方法。在本综述中，我们概述了IgG亚类的生物学和临床相关性，并总结了当前合理的治疗方法。
