Chou C C, Hsieh K H, Lin Y Z, Ting C K, Wang J Y
Department of Pediatrics, College of Medicine, National Taiwan University, Taipei, Republic of China.
Asian Pac J Allergy Immunol. 1988 Dec;6(2):129-33.
Two patients with recurrent sinopulmonary infections and normal total serum immunoglobulin levels were found to have selective deficiencies in IgG subclasses. The serum of one patient contained abnormally low IgG2 and IgG4; and the other was deficient in IgG4. Both patients responded to the treatment with high dose intravenous immunoglobulin. The experiences on these two cases strongly suggest that IgG subclasses should be checked in patients with recurrent sinopulmonary infections in face of normal total immunoglobulins.
两名患有复发性鼻窦肺部感染且血清总免疫球蛋白水平正常的患者被发现存在IgG亚类选择性缺陷。一名患者的血清中IgG2和IgG4异常低；另一名患者缺乏IgG4。两名患者对高剂量静脉注射免疫球蛋白治疗均有反应。这两个病例的经验强烈表明，对于复发性鼻窦肺部感染且总免疫球蛋白正常的患者，应检查其IgG亚类。
