Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Eur Arch Psychiatry Clin Neurosci. 2012 Jun;262(4):313-20. doi: 10.1007/s00406-011-0277-4. Epub 2011 Dec 20.
Previous studies on the association between affective disorders and the metabolic syndrome yielded inconclusive results. Therefore, we examined the prevalence of the metabolic syndrome in 230 men and women with unipolar major depressive disorder during inpatient treatment and compared it to 1,673 subjects from primary care from a similar region in northern Germany. We used the AHA/NHBLI criteria to determine the rate of metabolic syndrome (MetS) and each single criterion of MetS in both groups. The age-standardized prevalence of MetS was 2.4× as high in patients with major depressive disorder (MDD) compared with data from comparison subjects (41.0% vs. 17.0%). With respect to the single criteria, elevations were found in MDD patients for fasting glucose and triglycerides in both genders, and waist circumference in women. Men in the patient and the comparison groups were found to have higher rates of increased fasting glucose and triglycerides than women in the respective groups. Factors associated with the MetS in MDD patients comprise body mass index and the severity of depression. Our results demonstrate an increased prevalence of the MetS in men and women with MDD. Interventions for the frequently untreated metabolic abnormalities and careful screening for physical health conditions among people with MDD are warranted.
先前关于情感障碍与代谢综合征之间关联的研究结果并不一致。因此，我们调查了 230 名单相重性抑郁障碍住院患者中代谢综合征的患病率，并将其与来自德国北部同一地区初级保健机构的 1673 名对照受试者进行了比较。我们使用 AHA/NHBLI 标准来确定代谢综合征（MetS）的发生率以及两组中 MetS 的每个单一标准。与对照受试者相比（41.0%对 17.0%），患有重性抑郁障碍（MDD）的患者中 MetS 的年龄标准化患病率高出 2.4 倍。就单一标准而言，在男性和女性 MDD 患者中，空腹血糖和甘油三酯升高，女性腰围增大。在患者组和对照组中，男性空腹血糖和甘油三酯升高的发生率均高于相应组的女性。与 MDD 患者代谢综合征相关的因素包括体重指数和抑郁严重程度。我们的研究结果表明，MDD 患者中代谢综合征的患病率增加。有必要对 MDD 患者进行代谢异常的治疗和对身体健康状况的仔细筛查。
