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1
The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia.
Cell Rep. 2016 Jan 26;14(3):547-559. doi: 10.1016/j.celrep.2015.12.055. Epub 2016 Jan 7.
2
Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.
Cell Rep. 2015 Sep 1;12(9):1445-55. doi: 10.1016/j.celrep.2015.07.052. Epub 2015 Aug 20.
3
Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms.
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9545-9550. doi: 10.1073/pnas.1811727115. Epub 2018 Sep 4.
4
Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway.
Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2322755121. doi: 10.1073/pnas.2322755121. Epub 2024 Aug 20.
5
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Cell. 2012 Sep 14;150(6):1196-208. doi: 10.1016/j.cell.2012.07.032.
6
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Cell. 2010 Apr 16;141(2):290-303. doi: 10.1016/j.cell.2010.02.024. Epub 2010 Apr 8.
8
The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex.
Dev Cell. 2018 Nov 5;47(3):319-330.e5. doi: 10.1016/j.devcel.2018.10.003.
9
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9.
Mol Cell Biol. 2015 Jul;35(14):2479-94. doi: 10.1128/MCB.00125-15. Epub 2015 May 11.
10
Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex.
Mol Cell. 2017 Dec 7;68(5):835-846.e3. doi: 10.1016/j.molcel.2017.10.016. Epub 2017 Nov 5.

引用本文的文献

1
Rag GTPases control lysosomal acidification by regulating v-ATPase assembly in Drosophila.
J Biol Chem. 2025 Jul;301(7):110400. doi: 10.1016/j.jbc.2025.110400. Epub 2025 Jun 19.
3
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources.
Nat Cell Biol. 2024 Nov;26(11):1918-1933. doi: 10.1038/s41556-024-01523-7. Epub 2024 Oct 9.
4
Crosstalk between macrophages and immunometabolism and their potential roles in tissue repair and regeneration.
Heliyon. 2024 Sep 18;10(18):e38018. doi: 10.1016/j.heliyon.2024.e38018. eCollection 2024 Sep 30.
5
Ragopathies and the rising influence of RagGTPases on human diseases.
Nat Commun. 2024 Jul 10;15(1):5812. doi: 10.1038/s41467-024-50034-4.
8
The Cl- transporter ClC-7 is essential for phagocytic clearance by microglia.
J Cell Sci. 2024 Feb 15;137(4). doi: 10.1242/jcs.261616. Epub 2024 Feb 16.
10
Evolutionary analysis of the mTOR pathway provide insights into lifespan extension across mammals.
BMC Genomics. 2023 Aug 15;24(1):456. doi: 10.1186/s12864-023-09554-4.

本文引用的文献

1
Microglia in Health and Disease.
Cold Spring Harb Perspect Biol. 2015 Sep 9;8(1):a020560. doi: 10.1101/cshperspect.a020560.
2
Immune attack: the role of inflammation in Alzheimer disease.
Nat Rev Neurosci. 2015 Jun;16(6):358-72. doi: 10.1038/nrn3880.
3
The SLC7A7 Transporter Identifies Microglial Precursors prior to Entry into the Brain.
Cell Rep. 2015 May 19;11(7):1008-17. doi: 10.1016/j.celrep.2015.04.028. Epub 2015 May 7.
4
Differential requirement for irf8 in formation of embryonic and adult macrophages in zebrafish.
PLoS One. 2015 Jan 23;10(1):e0117513. doi: 10.1371/journal.pone.0117513. eCollection 2015.
5
The phosphate exporter xpr1b is required for differentiation of tissue-resident macrophages.
Cell Rep. 2014 Sep 25;8(6):1659-1667. doi: 10.1016/j.celrep.2014.08.018. Epub 2014 Sep 15.
6
Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection.
J Neurosci. 2014 Aug 20;34(34):11485-503. doi: 10.1523/JNEUROSCI.0210-14.2014.
7
Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126.
Sci Signal. 2014 Aug 12;7(338):ra76. doi: 10.1126/scisignal.2005347.
8
Rag GTPases are cardioprotective by regulating lysosomal function.
Nat Commun. 2014 Jul 1;5:4241. doi: 10.1038/ncomms5241.
9
RagA, but not RagB, is essential for embryonic development and adult mice.
Dev Cell. 2014 May 12;29(3):321-9. doi: 10.1016/j.devcel.2014.03.017. Epub 2014 Apr 24.
10
Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.
Cell. 2014 Feb 13;156(4):786-99. doi: 10.1016/j.cell.2014.01.024.

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