Fernández-Pérez Leandro, de Mirecki-Garrido Mercedes, Guerra Borja, Díaz Mario, Díaz-Chico Juan Carlos
Institute for Research in Biomedicine and Health (IUIBS), University of Las Palmas de Gran Canaria, Molecular and Translational Pharmacology - BioPharm Group, Las Palmas de G.C., Spain.
Institute for Research in Biomedicine and Health (IUIBS), University of Las Palmas de Gran Canaria, Molecular and Translational Pharmacology - BioPharm Group, Las Palmas de G.C., Spain.
Endocrinol Nutr. 2016 Apr;63(4):171-80. doi: 10.1016/j.endonu.2015.11.004. Epub 2016 Jan 7.
GH and sex hormones are critical regulators of body growth and composition, somatic development, intermediate metabolism, and sexual dimorphism. Deficiencies in GH- or sex hormone-dependent signaling and the influence of sex hormones on GH biology may have a dramatic impact on liver physiology during somatic development and in adulthood. Effects of sex hormones on the liver may be direct, through hepatic receptors, or indirect by modulating endocrine, metabolic, and gender-differentiated functions of GH. Sex hormones can modulate GH actions by acting centrally, regulating pituitary GH secretion, and peripherally, by modulating GH signaling pathways. The endocrine and/or metabolic consequences of long-term exposure to sex hormone-related compounds and their influence on the GH-liver axis are largely unknown. A better understanding of these interactions in physiological and pathological states will contribute to preserve health and to improve clinical management of patients with growth, developmental, and metabolic disorders.
生长激素（GH）和性激素是身体生长与组成、躯体发育、中间代谢以及性别差异的关键调节因子。GH或性激素依赖性信号传导的缺陷以及性激素对GH生物学的影响，可能在躯体发育期间及成年期对肝脏生理产生显著影响。性激素对肝脏的作用可能是直接的，通过肝脏受体起作用，也可能是间接的，通过调节GH的内分泌、代谢及性别分化功能来实现。性激素可通过中枢作用调节垂体GH分泌，以及通过外周作用调节GH信号通路，从而调节GH的作用。长期接触性激素相关化合物的内分泌和/或代谢后果及其对GH-肝脏轴的影响在很大程度上尚不清楚。更好地了解这些生理和病理状态下的相互作用，将有助于维护健康，并改善生长、发育和代谢紊乱患者的临床管理。
