Olmos Y, Carlton J G
Division of Cancer Studies, Section of Cell Biology and Imaging, King's College London, London SE1 1UL, United Kingdom.
Division of Cancer Studies, Section of Cell Biology and Imaging, King's College London, London SE1 1UL, United Kingdom.
Curr Opin Cell Biol. 2016 Feb;38:1-11. doi: 10.1016/j.ceb.2015.12.001. Epub 2016 Jan 15.
The ESCRT machinery drives a diverse collection of membrane remodeling events, including multivesicular body biogenesis, release of enveloped retroviruses and both reformation of the nuclear envelope and cytokinetic abscission during mitotic exit. These events share the requirement for a topologically equivalent membrane remodeling for their completion and the cells deployment of the ESCRT machinery in these different contexts highlights its functionality as a transposable membrane-fission machinery. Here, we will examine recent data describing ESCRT-III dependent membrane remodeling and explore new roles for the ESCRT-III complex at the nuclear envelope.
内体分选转运复合体（ESCRT）机制驱动着一系列多样的膜重塑事件，包括多泡体生物发生、包膜逆转录病毒的释放，以及有丝分裂退出过程中核膜的重新形成和胞质分裂切割。这些事件都需要进行拓扑学上等效的膜重塑才能完成，而细胞在这些不同情况下对ESCRT机制的运用凸显了其作为一种可转位的膜裂变机制的功能。在这里，我们将研究描述ESCRT-III依赖性膜重塑的最新数据，并探索ESCRT-III复合体在核膜处的新作用。
