• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells.

作者信息

Chaube B, Bhat M K

机构信息

Laboratory No. 6, National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, Maharashtra 411007, India.

出版信息

Cell Death Dis. 2016 Jan 14;7(1):e2044. doi: 10.1038/cddis.2015.404.

DOI:10.1038/cddis.2015.404
PMID:26775698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4816182/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83e/4816182/a9eec114b9f7/cddis2015404f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83e/4816182/a9eec114b9f7/cddis2015404f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c83e/4816182/a9eec114b9f7/cddis2015404f1.jpg

相似文献

1
AMPK, a key regulator of metabolic/energy homeostasis and mitochondrial biogenesis in cancer cells.AMPK是癌细胞代谢/能量稳态和线粒体生物发生的关键调节因子。
Cell Death Dis. 2016 Jan 14;7(1):e2044. doi: 10.1038/cddis.2015.404.
2
Cholinesterase Inhibitor Donepezil Increases Mitochondrial Biogenesis through AMP-Activated Protein Kinase in the Hippocampus.胆碱酯酶抑制剂多奈哌齐通过海马体中的AMP激活蛋白激酶增加线粒体生物合成。
Neuropsychobiology. 2016;73(2):81-91. doi: 10.1159/000441522. Epub 2016 Mar 23.
3
Regulation and function of AMPK in physiology and diseases.AMPK在生理和疾病中的调节作用及功能
Exp Mol Med. 2016 Jul 15;48(7):e245. doi: 10.1038/emm.2016.81.
4
The Role of AMPK Pathway in Neuroprotection.AMPK信号通路在神经保护中的作用。
Adv Exp Med Biol. 2016;854:425-30. doi: 10.1007/978-3-319-17121-0_56.
5
The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator.腺苷酸活化蛋白激酶（AMPK）与癌症：代谢调控因子的多面性。
Cancer Lett. 2015 Jan 28;356(2 Pt A):165-70. doi: 10.1016/j.canlet.2014.01.018. Epub 2014 Jan 28.
6
Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats.芦丁通过激活AMPK增加高脂饮食诱导的肥胖大鼠的肌肉线粒体生物合成。
Nutrients. 2015 Sep 22;7(9):8152-69. doi: 10.3390/nu7095385.
7
Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing.糖酵解和AMPK的联合抑制诱导协同性乳腺癌细胞杀伤。
Breast Cancer Res Treat. 2015 Jun;151(3):529-39. doi: 10.1007/s10549-015-3386-3. Epub 2015 May 15.
8
Adiponectin prevents reduction of lipid-induced mitochondrial biogenesis via AMPK/ACC2 pathway in chicken adipocyte.脂联素通过鸡脂肪细胞中的AMPK/ACC2途径防止脂质诱导的线粒体生物发生减少。
J Cell Biochem. 2015 Jun;116(6):1090-100. doi: 10.1002/jcb.25064.
9
Identification of AMP-activated protein kinase targets by a consensus sequence search of the proteome.通过蛋白质组的共有序列搜索鉴定AMP激活的蛋白激酶靶点。
BMC Syst Biol. 2015 Mar 11;9:13. doi: 10.1186/s12918-015-0156-0.
10
AMP-activated protein kinase and cancer.腺苷酸活化蛋白激酶与癌症。
Acta Physiol (Oxf). 2009 May;196(1):55-63. doi: 10.1111/j.1748-1716.2009.01980.x. Epub 2009 Feb 25.

引用本文的文献

1
Synergistic effects and mechanism of recombinant viral vector-mediated STAT1 overexpression and STAT3 silencing on glioma U251 apoptosis.重组病毒载体介导的STAT1过表达和STAT3沉默对胶质瘤U251细胞凋亡的协同作用及机制
Mol Biol Rep. 2025 May 22;52(1):482. doi: 10.1007/s11033-025-10585-1.
2
Impact of lactate on immune cell function in the tumor microenvironment: mechanisms and therapeutic perspectives.乳酸对肿瘤微环境中免疫细胞功能的影响：机制与治疗前景
Front Immunol. 2025 Mar 26;16:1563303. doi: 10.3389/fimmu.2025.1563303. eCollection 2025.
3
Molecular Mechanisms Underlying Heart Failure and Their Therapeutic Potential.

本文引用的文献

1
AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1α-mediated mitochondrial biogenesis.腺苷酸活化蛋白激酶（AMPK）通过调节p38/过氧化物酶体增殖物激活受体γ共激活因子1α（PGC-1α）介导的线粒体生物合成来维持癌细胞的能量稳态和生存。
Cell Death Discov. 2015 Dec 21;1:15063. doi: 10.1038/cddiscovery.2015.63. eCollection 2015.
2
Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts.雷帕霉素靶蛋白活性降低可促进线粒体逆行信号传递并增加正常人成纤维细胞的寿命。
Aging Cell. 2013 Dec;12(6):966-77. doi: 10.1111/acel.12122. Epub 2013 Jul 30.
3
心力衰竭的分子机制及其治疗潜力。
Cells. 2025 Feb 20;14(5):324. doi: 10.3390/cells14050324.
4
Dietary Bacillus subtilis benefits meat quality by regulating the muscle fiber type and antioxidant capacity of broilers.日粮中的枯草芽孢杆菌通过调节肉鸡的肌纤维类型和抗氧化能力来改善肉质。
Poult Sci. 2024 Dec;103(12):104267. doi: 10.1016/j.psj.2024.104267. Epub 2024 Aug 25.
5
TRIM28 in cancer and cancer therapy.TRIM28与癌症及癌症治疗
Front Genet. 2024 Jul 19;15:1431564. doi: 10.3389/fgene.2024.1431564. eCollection 2024.
6
EP4-induced mitochondrial localization and cell migration mediated by CALML6 in human oral squamous cell carcinoma.CALML6 通过 EP4 诱导的线粒体定位和细胞迁移促进人口腔鳞状细胞癌的转移
Commun Biol. 2024 May 14;7(1):567. doi: 10.1038/s42003-024-06231-4.
7
Metformin and risk of hematological cancers in patients with diabetes: a systematic review and meta-analysis.二甲双胍治疗糖尿病患者与血液系统恶性肿瘤风险的系统评价和 Meta 分析。
Ann Saudi Med. 2024 Mar-Apr;44(2):126-134. doi: 10.5144/0256-4947.2024.126. Epub 2024 Apr 4.
8
Integrin αvβ3 Upregulation in Response to Nutrient Stress Promotes Lung Cancer Cell Metabolic Plasticity.营养压力诱导整合素αvβ3 上调促进肺癌细胞代谢可塑性
Cancer Res. 2024 May 15;84(10):1630-1642. doi: 10.1158/0008-5472.CAN-23-2700.
9
AMPK Signaling Pathway as a Potential Therapeutic Target for Parkinson's Disease.AMPK信号通路作为帕金森病的潜在治疗靶点
Adv Pharm Bull. 2024 Mar;14(1):120-131. doi: 10.34172/apb.2024.013. Epub 2023 Oct 14.
10
The Oligostilbene Gnetin H Is a Novel Glycolysis Inhibitor That Regulates Thioredoxin Interacting Protein Expression and Synergizes with OXPHOS Inhibitor in Cancer Cells.橄榄苦苷 Gnetin H 是一种新型糖酵解抑制剂，可调节硫氧还蛋白相互作用蛋白的表达，并与癌细胞中的 OXPHOS 抑制剂协同作用。
Int J Mol Sci. 2023 Apr 23;24(9):7741. doi: 10.3390/ijms24097741.
The LKB1-AMPK pathway-friend or foe in cancer?
LKB1-AMPK 通路——癌症的朋友还是敌人？
Cancer Cell. 2013 Feb 11;23(2):131-2. doi: 10.1016/j.ccr.2013.01.009.
4
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.AMPK 调节 NADPH 稳态以促进能量应激时肿瘤细胞的存活。
Nature. 2012 May 9;485(7400):661-5. doi: 10.1038/nature11066.
5
AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases.AMPK介导的糖酵解增加作为人类细胞对氧化应激的适应性反应：对线粒体疾病中细胞存活的影响
Biochim Biophys Acta. 2012 Feb;1822(2):233-47. doi: 10.1016/j.bbadis.2011.09.014. Epub 2011 Oct 6.
6
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.AMP 激活的蛋白激酶：一种能量感受器，调节细胞功能的各个方面。
Genes Dev. 2011 Sep 15;25(18):1895-908. doi: 10.1101/gad.17420111.
7
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply.TSC 缺失细胞的葡萄糖成瘾是由 mTORC1 依赖性代谢需求与供应平衡失败引起的。
Mol Cell. 2010 May 28;38(4):487-99. doi: 10.1016/j.molcel.2010.05.007.
8
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle.简短高强度间歇运动可激活AMPK和p38 MAPK信号通路，并增加人骨骼肌中PGC-1α的表达。
J Appl Physiol (1985). 2009 Mar;106(3):929-34. doi: 10.1152/japplphysiol.90880.2008. Epub 2008 Dec 26.
9
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice.靶向乳酸供能呼吸可选择性杀死小鼠体内的缺氧肿瘤细胞。
J Clin Invest. 2008 Dec;118(12):3930-42. doi: 10.1172/JCI36843. Epub 2008 Nov 20.
10
The tumor microenvironment and metastatic disease.肿瘤微环境与转移性疾病。
Clin Exp Metastasis. 2009;26(1):19-34. doi: 10.1007/s10585-008-9182-2. Epub 2008 Jun 10.