盐负荷对自发性高血压大鼠和Wistar-Kyoto大鼠红细胞变形性的影响。

Effect of salt-loading on erythrocyte deformability in spontaneously hypertensive and Wistar-Kyoto rats.

作者信息

Murakawa K, Kohno M, Yasunari K, Yokokawa K, Kurihara N, Nagasawa T, Kinoshita Y, Takeda T

机构信息

First Department of Internal Medicine, Osaka City University Medical School, Japan.

出版信息

Life Sci. 1989;45(12):1089-95. doi: 10.1016/0024-3205(89)90166-5.

DOI:10.1016/0024-3205(89)90166-5

PMID:2677571

Abstract

Effects of salt-loading on erythrocyte and erythrocyte ghost deformabilities were measured by laser diffractometry using a flat cell and a helium-neon laser in spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY). Salt-loading did not affect the deformability of erythrocytes in SHR and WKY, although a significantly reduced deformability was observed in salt-loaded SHR compared with values in control WKY and salt-loaded WKY (p less than 0.05, p less than 0.05, respectively). In contrast, salt-loading significantly reduced the deformability of erythrocyte ghosts in WKY and SHR (p less than 0.05, p less than 0.05, respectively). Our results suggest that salt-loading reduces erythrocyte membrane viscoelasticity in both WKY and SHR, and that the observed reduction of ghost deformability induced by salt-loading may influence the peripheral circulation.

摘要

通过使用扁平细胞和氦氖激光的激光衍射法，在自发性高血压大鼠（SHR）和年龄匹配的正常血压Wistar-Kyoto大鼠（WKY）中测量了盐负荷对红细胞和红细胞血影变形能力的影响。盐负荷对SHR和WKY中的红细胞变形能力没有影响，尽管与对照WKY和盐负荷WKY的值相比，在盐负荷的SHR中观察到变形能力显著降低（分别为p<0.05，p<0.05）。相比之下，盐负荷显著降低了WKY和SHR中红细胞血影的变形能力（分别为p<0.05，p<0.05）。我们的结果表明，盐负荷降低了WKY和SHR中红细胞膜的粘弹性，并且观察到的盐负荷诱导的血影变形能力降低可能会影响外周循环。