Tarricone Rosanna, Ricca Giada, Nyanzi-Wakholi Barbara, Medina-Lara Antonieta
Centre for Research on Health and Social Care Management (CERGAS), Milan, Italy; Department of Policy Analysis and Public Management, Bocconi University, Milan, Italy.
Centre for Research on Health and Social Care Management (CERGAS), Milan, Italy.
Crit Rev Oncol Hematol. 2016 Mar;99:49-62. doi: 10.1016/j.critrevonc.2015.12.008. Epub 2015 Dec 22.
Cancer anorexia-cachexia syndrome (CACS) negatively impacts patients' quality of life (QoL) and increases the burden on healthcare resources.
To review published CACS data regarding health-related QOL (HRQoL) and its economic impact on the healthcare system.
Searches were conducted in MEDLINE, EMBASE, DARE, and NHS EED databases.
A total of 458 HRQoL and 189 healthcare resources utilisation abstracts were screened, and 42 and 2 full-text articles were included, respectively. The EORTC QLQ-C30 and FAACT instruments were most favoured for assessing HRQOL but none of the current tools cover all domains affected by CACS. Economic estimates for managing CACS are scarce, with studies lacking a breakdown of healthcare resource utilisation items.
HRQoL instruments that can better assess and incorporate all the domains affected by CACS are required. Rigorous assessment of costs and benefits of treatment are needed to understand the magnitude of the impact of CACS.
癌症恶病质厌食综合征（CACS）对患者的生活质量（QoL）产生负面影响，并增加了医疗资源的负担。
回顾已发表的关于CACS与健康相关生活质量（HRQoL）及其对医疗系统经济影响的数据。
在MEDLINE、EMBASE、DARE和NHS EED数据库中进行检索。
共筛选了458篇HRQoL和189篇医疗资源利用摘要，分别纳入了42篇和2篇全文文章。欧洲癌症研究与治疗组织生活质量核心问卷（EORTC QLQ-C30）和癌症厌食-恶病质综合征功能评估量表（FAACT）是评估HRQoL最常用的工具，但目前没有一种工具涵盖了CACS影响的所有领域。管理CACS的经济评估很少，研究缺乏对医疗资源利用项目的细分。
需要能够更好地评估和纳入CACS影响的所有领域的HRQoL工具。需要对治疗的成本和效益进行严格评估，以了解CACS的影响程度。
