Miquel S, Martín R, Lashermes A, Gillet M, Meleine M, Gelot A, Eschalier A, Ardid D, Bermúdez-Humarán L G, Sokol H, Thomas M, Theodorou V, Langella P, Carvalho F A
INRA, Commensal and Probiotics-Host Interactions Laboratory, UMR 1319 Micalis, F-78350 Jouy-en-Josas, France.
AgroParisTech, UMR1319 Micalis, F-78350 Jouy-en-Josas, France.
Sci Rep. 2016 Jan 18;6:19399. doi: 10.1038/srep19399.
Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.
内脏疼痛和肠道菌群失调与肠易激综合征（IBS）有关，这是一种常见的功能性胃肠疾病，目前尚无有效的治疗方法。在本研究中，在由新生母体分离（NMS）应激诱导的IBS样啮齿动物模型中，观察到普拉梭菌的存在减少。此外，还研究了普拉梭菌是否可能对结肠敏感性产生影响。A2-165参考菌株，而非其上清液，显著降低了由小鼠NMS或大鼠部分束缚应激诱导的结肠超敏反应。这种作用与肠上皮屏障的增强有关。因此，普拉梭菌具有抗伤害感受特性，表明其有治疗IBS患者腹痛的潜力。
