Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
PLoS One. 2013 Jul 3;8(7):e67759. doi: 10.1371/journal.pone.0067759. Print 2013.
To examine whether serum uric acid (SUA) is associated with 2-hour postload glucose (2-h PG) in Chinese with impaired fasting plasma glucose (IFG) and/or HbA1c (IA1C).
Anthropometric and biochemical examinations, such as SUA concentration, were performed in 3763 individuals from all the villages in Baqiao County, China. A 75-g oral glucose tolerance test (OGTT) was conducted in 1197 Chinese with prediabetes as having IFG (110 ≤ fasting plasma glucose [FPG] <126 mg/dl and HbA1c <6.5%), IA1C (5.7% ≤ HbA1c <6.5% and FPG <126 mg/dl), or both.
The present study included 1197 participants with IFG and/or IA1C (mean age 56.5 ± 10.3 years; 50.6% men). In multivariate linear regression, after adjustment for gender, age, smoking and drinking, body mass index (BMI), systolic and diastolic blood pressure (SBP, DBP), lipid profiles, logarithmic transformed C-reactive protein (log-CRP), estimated glomerular filtration rate (e-GFR), FPG and HbA1c, with a 1-mg/dl increment of SUA, 2-h PG increased by 5.04 ± 0.72 (P<0.001), 3.06 ± 1.08 (P = 0.001), 5.40 ± 1.26 (P<0.001), and 2.34 ± 2.16 mg/dl (P = 0.056) in all participants, in participants with normal glucose tolerance (NGT), with impaired glucose tolerance (IGT), and with 2-h newly diagnosed diabetes (2-h NDM, with 2-h PG ≥ 200 mg/dl), respectively. In both men and women, 2-h PG increased progressively and significantly from the lower to the upper SUA tertiles (P<0.001). Moreover, in multivariate logistic regression, 1-standard deviation (SD; 1.53 mg/dl) increment of SUA was significantly associated with a 36% higher risk for 2-h NDM (Odds ratio [CI 95%]: 1.36 [1.09-1.99]; P = 0.03).
SUA is significantly associated with 2-h PG in Chinese with IFG and/or IA1C.
研究血清尿酸（SUA）与中国空腹血糖受损（IFG）和/或糖化血红蛋白（IA1C）人群的 2 小时餐后血糖（2-h PG）之间的关系。
在中国灞桥区所有村庄的 3763 名个体中进行了人体测量和生化检查，如 SUA 浓度。对 1197 名患有糖尿病前期的中国人进行了 75g 口服葡萄糖耐量试验（OGTT），这些人被诊断为 IFG（110≤空腹血糖[FPG] <126mg/dl 和 HbA1c <6.5%）、IA1C（5.7%≤HbA1c <6.5%和 FPG <126mg/dl）或两者兼有。
本研究共纳入 1197 名 IFG 和/或 IA1C 患者（平均年龄 56.5±10.3 岁；50.6%为男性）。在多元线性回归中，在校正性别、年龄、吸烟和饮酒、体重指数（BMI）、收缩压和舒张压（SBP、DBP）、血脂谱、对数转化的 C 反应蛋白（log-CRP）、估计肾小球滤过率（e-GFR）、FPG 和 HbA1c 后，SUA 增加 1mg/dl，2-h PG 分别增加 5.04±0.72（P<0.001）、3.06±1.08（P=0.001）、5.40±1.26（P<0.001）和 2.34±2.16mg/dl（P=0.056）。在所有参与者、糖耐量正常（NGT）者、葡萄糖耐量受损（IGT）者和 2 小时新诊断糖尿病（2-h NDM，2-h PG≥200mg/dl）者中均如此。在男性和女性中，2-h PG 从 SUA 的较低三分位到较高三分位均呈显著升高趋势（P<0.001）。此外，在多元逻辑回归中，SUA 增加 1 个标准差（SD；1.53mg/dl）与 2-h NDM 的风险增加 36%显著相关（优势比[95%CI]：1.36[1.09-1.99]；P=0.03）。
SUA 与中国 IFG 和/或 IA1C 人群的 2-h PG 显著相关。
