Department of Public Health, University of Helsinki, Helsinki, Finland.
Diab Vasc Dis Res. 2010 Jan;7(1):40-6. doi: 10.1177/1479164109347408. Epub 2009 Oct 13.
The objective of this study was to investigate the association of serum UA with either FPG or 2hPG levels among Chinese adults in Qingdao, China. A population-based survey for diabetes was performed in 2006 in Qingdao. The survey included 1,490 men and 2,325 women aged 35-74 years who had data stored as required for the current data analysis. The association of mean UA with plasma glucose was tested using a linear regression model. Serum UA concentration raised with increasing FPG levels up to FPG of 7.0 mmol/l, but significantly decreased thereafter with further increase in FPG levels. The multivariate adjusted beta coefficient between FPG and UA in individuals with newly diagnosed diabetes was -0.20 for men and -0.27 for women (p<0.01 for both). A declining trend for the UA concentration was also observed at 2hPG of 10 mmol/l or higher in both genders. Fasting serum UA levels was higher in the pre-diabetic population but lower in people with diabetes than in normoglycaemic people. UA may serve as a potential biomarker of deterioration in glucose metabolism, but its clinical implication need to be further studied.
本研究旨在探讨中国青岛成年人血清尿酸（UA）与空腹血糖（FPG）或 2 小时血糖（2hPG）之间的关系。2006 年在青岛进行了一项基于人群的糖尿病调查。该调查纳入了年龄在 35-74 岁之间的 1490 名男性和 2325 名女性，他们的数据符合当前数据分析的要求。采用线性回归模型检验平均 UA 与血浆葡萄糖之间的关系。结果显示，随着 FPG 水平的升高，血清 UA 浓度逐渐升高，直至 FPG 达到 7.0mmol/L，但此后随着 FPG 水平的进一步升高，UA 浓度显著下降。在新诊断为糖尿病的个体中，FPG 和 UA 之间的多变量调整后β系数分别为男性-0.20 和女性-0.27（均<0.01）。在男女两性中，2hPG 达到 10mmol/L 或更高时，UA 浓度也呈下降趋势。在糖尿病前期人群中，空腹血清 UA 水平较高，但在糖尿病患者中，UA 水平低于血糖正常人群。UA 可能是葡萄糖代谢恶化的潜在生物标志物，但仍需要进一步研究其临床意义。
