姜黄素葡糖醛酸苷（主要的姜黄素代谢产物）的抗氧化能力的合成与评估
Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites.
作者信息
Choudhury Ambar K, Raja Suganya, Mahapatra Sanjata, Nagabhushanam Kalyanam, Majeed Muhammed
机构信息
Sami Labs Limited, Bangalore 560058, India.
Sabinsa Corporation-East Windsor, NJ 08520, USA.
出版信息
Antioxidants (Basel). 2015 Dec 2;4(4):750-67. doi: 10.3390/antiox4040750.
Abstract
Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging method and Oxygen Radical Absorbance Capacity (ORAC) assay. The results show that curcumin monoglucuronide exhibits 10 fold less anti-oxidant activity (DPPH method) and the anti-oxidant capacity of curcumin diglucuronide is highly attenuated compared to the anti-oxidant activity of curcumin.
摘要
姜黄素代谢产物，即姜黄素单葡萄糖醛酸苷和姜黄素双葡萄糖醛酸苷，采用另一种合成方法合成。使用二苯基苦味酰基自由基（DPPH）清除法和氧自由基吸收能力（ORAC）测定法，将这些姜黄素葡萄糖醛酸苷的抗氧化潜力与姜黄素的抗氧化潜力进行了比较。结果表明，姜黄素单葡萄糖醛酸苷的抗氧化活性（DPPH法）低10倍，与姜黄素的抗氧化活性相比，姜黄素双葡萄糖醛酸苷的抗氧化能力大大减弱。
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