间充质干细胞通过含姜黄素的纳米支架进行成骨分化

Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds.

作者信息

Khezri Khadijeh, Maleki Dizaj Solmaz, Rahbar Saadat Yalda, Sharifi Simin, Shahi Shahriar, Ahmadian Elham, Eftekhari Aziz, Dalir Abdolahinia Elaheh, Lotfipour Farzaneh

机构信息

Deputy of Food and Drug Administration, Urmia University of Medical Sciences, Urmia, Iran.

Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Stem Cells Int. 2021 Jul 17;2021:1520052. doi: 10.1155/2021/1520052. eCollection 2021.

DOI:10.1155/2021/1520052

PMID:34335789

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8313343/

Abstract

The diverse pleiotropic pharmacological effects of curcumin nanoformulations have turned it into an attractive natural compound in different health-related problems. A great body of evidence has shown the impact of curcumin and its nanoformulations on the differentiation of stem cells. The current review highlights cellular and molecular mechanisms connected with the osteogenic differentiation of mesenchymal stem cells (MSCs) in the scaffolds benefiting from the presence of nanocurcumin pointing toward the role of inhibitory or stimulant signal transduction pathways in detail. Moreover, the effects of different concentrations as well as the structural modifications of curcumin on the differentiation of MSCs have been addressed.

摘要

姜黄素纳米制剂多样的多效药理作用使其成为解决各种健康相关问题的极具吸引力的天然化合物。大量证据表明了姜黄素及其纳米制剂对干细胞分化的影响。本综述重点介绍了在含有纳米姜黄素的支架中，与间充质干细胞（MSCs）成骨分化相关的细胞和分子机制，详细指出了抑制或刺激信号转导通路的作用。此外，还探讨了不同浓度的姜黄素以及其结构修饰对MSCs分化的影响。