Darmonkow Alexander, Rowe Zoë E M, Harding Scott V
Faculty of Medicine, Memorial University, St. John's, NL, Canada.
Department of Biochemistry, Faculty of Science, Memorial University, St. John's, NL, Canada.
Open Life Sci. 2025 Jul 18;20(1):20251112. doi: 10.1515/biol-2025-1112. eCollection 2025.
Here, we provide a current review of strategies aimed at improving the bioavailability of curcuminoids, a group of compounds with therapeutic potential. This review discusses formulations from the traditional supplementation approaches to the innovative methods to enhance solubility and bioavailability, including cyclodextrins and hydrophilic carriers. Additionally, colloidal delivery strategies, such as micelles, liposomes, solid lipid particles, and emulsions, are examined as promising vehicles for curcuminoid delivery. The review underscores the importance of clinical trials in assessing the efficacy of these formulations and highlights a pivotal yet frequently neglected factor in curcuminoid research: the differentiation between total and free curcuminoid quantification. In summary, this concise review evaluates existing curcuminoid formulations and explores innovative approaches to improve their bioavailability.
在此，我们对旨在提高姜黄素类化合物生物利用度的策略进行了当前综述，姜黄素类化合物是一组具有治疗潜力的化合物。本综述讨论了从传统补充方法到提高溶解度和生物利用度的创新方法的制剂，包括环糊精和亲水性载体。此外，还研究了胶体递送策略，如胶束、脂质体、固体脂质颗粒和乳液，作为姜黄素类化合物递送的有前景的载体。该综述强调了临床试验在评估这些制剂疗效方面的重要性，并突出了姜黄素类化合物研究中一个关键但经常被忽视的因素：总姜黄素类化合物定量和游离姜黄素类化合物定量之间的差异。总之，这篇简明综述评估了现有的姜黄素类化合物制剂，并探索了提高其生物利用度的创新方法。
