Ghazizadeh Matin, Alavi Amlashi Hesamodin, Mehrparvar Golfam
Department of Otorhinolaryngology, Head and Neck Surgery, Taleghani Hospital,Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Otorhinolaryngol. 2015 Jul;27(81):313-8.
Plasmacytoma is a monoclonal proliferation of plasma cells. It can be an isolated lesion, for which the term extramedullary plasmacytoma is used, or a representation of multiple myeloma.The upper respiratory tract is the most common site for an extramedullary plasmacytoma. Sinonasal plasmacytomas cause different symptoms depending on the sites of origins and the areas of involvement. The treatment of choice for extramedullary plasmacytoma is local radiotherapy. Although it is generally accepted that plasmacytomas are radiosensitive, there are reports of cases that do not respond to radiotherapy.
A case of a 24-year-old male diagnosed with radioresistant extramedullary plasmacytoma of the maxillary sinus, who responded to surgical treatment, is reported.
It is reasonable to consider an interdisciplinary approach in the management of extramedullary plasmacytoma. Considering early surgical intervention in cases encompassing risk factors of radiotherapy resistance is especially recommended before debilitating complications emerge.
浆细胞瘤是浆细胞的单克隆增殖。它可以是一个孤立性病变，称为髓外浆细胞瘤，也可以是多发性骨髓瘤的一种表现形式。上呼吸道是髓外浆细胞瘤最常见的部位。鼻窦浆细胞瘤根据起源部位和受累区域会引起不同症状。髓外浆细胞瘤的首选治疗方法是局部放疗。虽然一般认为浆细胞瘤对放疗敏感，但有报道称存在对放疗无反应的病例。
报告了一例24岁男性被诊断为上颌窦放疗抵抗性髓外浆细胞瘤，该病例对手术治疗有反应。
在髓外浆细胞瘤的管理中考虑采用多学科方法是合理的。尤其建议在出现使人衰弱的并发症之前，对于存在放疗抵抗风险因素的病例考虑早期手术干预。
