Mollayeva Tatyana, Pratt Brandy, Mollayeva Shirin, Shapiro Colin M, Cassidy J David, Colantonio Angela
Graduate Department of Rehabilitation Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Collaborative Program in Neuroscience, University of Toronto, Toronto, ON, Canada; Toronto Rehab-University Health Network, Toronto, ON, Canada.
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Sleep Med. 2016 Apr;20:157-66. doi: 10.1016/j.sleep.2015.09.008. Epub 2015 Oct 23.
AIM/BACKGROUND: The principal aim of this study was to, for the first time, examine the relationship between insomnia and perceived disability among workers with mild traumatic brain injury (mTBI)/concussion.
PATIENTS/METHODS: A cross-sectional study was conducted at the Workplace Safety and Insurance Board Clinic of the largest rehabilitation teaching hospital in Canada. Data from questionnaires, insurer records and clinical investigations were analysed. The Insomnia Severity Index measured the primary independent variable, and the Sheehan Disability Scale measured disability outcomes, classified as 'mild/moderate' or 'marked/extreme'. Two-sided t-tests and Chi-squared tests were used for bivariate associations. A binomial logistic regression model was fit using previously identified variables.
The sample comprised 92 workers (45.1 ± 9.9 years old, 61% male) with mTBI/concussion at median time 196 days after injury. When compared with workers reporting lower disability, workers with higher disability were found with more severe insomnia, depression, anxiety and pain. In the multivariable analysis, the odds of reporting higher global disability increased with increasing insomnia and pain [adjusted odds ratio (OR) 1.16 (95% CI 1.03-1.31) and 1.117 (95% CI 1.01-1.24), respectively]. Insomnia was the only significant covariate in a fully adjusted work disability model. None of the variables studied were statistically significant in the social and family life disability models.
Greater attention should be given to the diagnosis and management of insomnia in persons with mTBI/concussion.
目的/背景:本研究的主要目的是首次探讨轻度创伤性脑损伤(mTBI)/脑震荡工人中失眠与感知残疾之间的关系。
患者/方法:在加拿大最大的康复教学医院的 Workplace Safety and Insurance Board 诊所进行了一项横断面研究。对问卷调查、保险公司记录和临床调查的数据进行了分析。失眠严重程度指数测量主要自变量,Sheehan 残疾量表测量残疾结果,分为“轻度/中度”或“显著/极度”。双侧 t 检验和卡方检验用于双变量关联分析。使用先前确定的变量拟合二项逻辑回归模型。
样本包括 92 名 mTBI/脑震荡工人(年龄 45.1±9.9 岁,61%为男性),受伤后中位时间为 196 天。与报告残疾程度较低的工人相比,残疾程度较高的工人存在更严重的失眠、抑郁、焦虑和疼痛。在多变量分析中,报告更高总体残疾的几率随着失眠和疼痛的增加而增加[调整后的优势比(OR)分别为 1.16(95%置信区间 1.03 - 1.31)和 1.117(95%置信区间 1.01 - 1.24)]。失眠是完全调整后的工作残疾模型中唯一显著的协变量。在社会和家庭生活残疾模型中,所研究的变量均无统计学意义。
应更加关注 mTBI/脑震荡患者失眠的诊断和管理。