Gou Yan-You, Lin Susana, Que Danielle E, Tayo Lemmuel L, Lin Ding-Yan, Chen Kuan-Chung, Chen Fu-An, Chiang Pen-Chi, Wang Gen-Shuh, Hsu Yi-Chyuan, Chuang Kuo Pin, Chuang Chun-Yu, Tsou Tsui-Chun, Chao How-Ran
Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, Neipu, Pingtung County, 912, Taiwan.
International College, National Pingtung University of Science and Technology, Neipu, Pingtung County, 912, Taiwan.
Environ Sci Pollut Res Int. 2016 May;23(9):8518-28. doi: 10.1007/s11356-015-5946-9. Epub 2016 Jan 20.
Estrogen-like endocrine disrupting compounds (EEDC) such as bisphenol A, nonylphenol, and phthalic acid esters are toxic compounds that may occur in both raw- and drinking water. The aim of this study was to combine chemical- and bioassay to evaluate the risk of EEDCs in the drinking water treatment plants (DWTPs). Fifty-six samples were collected from seven DWTPs located in northern-, central-, and southern Taiwan from 2011 to 2012 and subjected to chemical analyses and two bioassay methods for total estrogenic activity (E-Screen and T47D-KBluc assay). Among of the considered EEDCs, only dibutyl phthalate (DBP) and di (2-ethylhexyl) phthalate (DEHP) were detected in both drinking and raw water samples. DBP levels in drinking water ranged from <MDL to 0.840 μg/L and from <MDL to 0.760 μg/L in raw water. DEHP had higher detection rate (82.1 %) than other compounds and was present in both drinking water and raw water from all the DWTPs. The highest daily drinking water intake calculated for male and female were 0.0823 and 0.115 μg/kg per day. The two selected bioassays were conducted for the first batch of 56 samples and a detection rate of 23 % for estradiol equivalent (EEQ) lower than the LOQ to 1.3 and 15 % for EEQ lower than LOQ to 0.757 for the second 53 samples. Our results showed a good correlation between E-screen and chemical assay which indicates that a combination of both can be used in detecting EEDCs in environmental samples.
双酚A、壬基酚和邻苯二甲酸酯等类雌激素内分泌干扰化合物（EEDC）是可能存在于原水和饮用水中的有毒化合物。本研究的目的是结合化学分析和生物测定法，评估饮用水处理厂（DWTP）中EEDC的风险。2011年至2012年期间，从台湾北部、中部和南部的7个DWTP采集了56个样本，并进行了化学分析以及两种总雌激素活性生物测定方法（E-Screen和T47D-KBluc测定）。在所考虑的EEDC中，仅在饮用水和原水样本中检测到邻苯二甲酸二丁酯（DBP）和邻苯二甲酸二（2-乙基己基）酯（DEHP）。饮用水中DBP的含量范围为<最低检测限至0.840μg/L，原水中为<最低检测限至0.760μg/L。DEHP的检出率（82.1%）高于其他化合物，且在所有DWTP的饮用水和原水中均有存在。男性和女性计算得出的最高每日饮用水摄入量分别为0.0823和0.115μg/kg/天。对首批56个样本进行了两种选定的生物测定，雌二醇当量（EEQ）低于最低定量限（LOQ）至1.3的检出率为23%，第二批53个样本中EEQ低于LOQ至0.757的检出率为15%。我们的结果表明，E-Screen与化学分析之间具有良好的相关性，这表明两者结合可用于检测环境样本中的EEDC。
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