Caprioli J, Ortiz-Colberg R, Miller J M, Tressler C
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven.
Am J Ophthalmol. 1989 Oct 15;108(4):404-13. doi: 10.1016/s0002-9394(14)73308-2.
We developed a method to quantify the surface contour of the peripapillary nerve fiber layer from simultaneous stereoscopic videographic images. Parameters that describe this contour are defined and compared to standard optic nerve structural parameters (cup/disk ratio, disk rim area, cup volume) in three age-matched groups of patients: 52 normal controls, 79 glaucoma suspects, and 101 glaucoma patients. Greater discriminatory information was obtained from the measurements from the superior and inferior quadrants than from the measurements from the temporal and nasal quadrants. This approach helps identify new structural markers that may more closely reflect the number of ganglion cell axons in the optic nerve. Such measurements made longitudinally in living eyes will provide valuable information about the relative rates of ganglion cell death in aging and in glaucoma.
我们开发了一种方法，可从同步立体视频图像中量化视乳头周围神经纤维层的表面轮廓。定义了描述该轮廓的参数，并将其与三组年龄匹配的患者的标准视神经结构参数（杯盘比、视盘边缘面积、杯体积）进行比较：52名正常对照者、79名青光眼疑似患者和101名青光眼患者。与颞侧和鼻侧象限的测量相比，从上方和下方象限的测量中获得了更多的鉴别信息。这种方法有助于识别可能更密切反映视神经中神经节细胞轴突数量的新结构标记。在活体眼中进行的纵向测量将提供有关衰老和青光眼中神经节细胞死亡相对速率的有价值信息。
