Caprioli J
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06510-8061.
Ophthalmology. 1990 Mar;97(3):358-65; discussion 365-6. doi: 10.1016/s0161-6420(90)32581-2.
Reliable structural markers for early glaucomatous optic nerve damage would facilitate the diagnosis of glaucoma at an early stage, possibly before visual field loss occurs. Computerized image analyses were used to develop and analyze new structural parameters for glaucomatous optic nerve damage. Multiple measurements of relative juxtapapillary nerve fiber layer height were made in glaucoma patients (n = 112), patients suspected of having glaucoma (n = 87), and in age-matched normal control subjects (n = 53). The average relative nerve fiber layer (NFL) height differed in glaucoma patients and normal subjects by 70 microns, but differences exceeded 100 microns at the superior and inferior poles of the disc. Mean values for "glaucoma suspects" were intermediate between those for the normal subjects and glaucoma groups. The ability of summary statistics of relative NFL height measurements to discriminate between normal and glaucomatous eyes was superior to that of the standard disc parameters cup-disc ratio, disc rim area, and cup volume. Measurements of relative NFL height correlated with indices of visual field loss; the strongest correlations occurred for measurements at the superior and inferior poles. Measurements of juxtapapillary NFL height may prove useful to detect glaucomatous optic nerve damage at an early stage and to accurately recognize progressive nerve damage over time.
用于早期青光眼性视神经损伤的可靠结构标志物将有助于在早期阶段，可能在视野丧失发生之前诊断青光眼。计算机图像分析被用于开发和分析青光眼性视神经损伤的新结构参数。对青光眼患者（n = 112）、疑似青光眼患者（n = 87）以及年龄匹配的正常对照受试者（n = 53）进行了相对视乳头旁神经纤维层高度的多次测量。青光眼患者和正常受试者的平均相对神经纤维层（NFL）高度相差70微米，但在视盘的上极和下极差异超过100微米。“疑似青光眼患者”的平均值介于正常受试者和青光眼组之间。相对NFL高度测量的汇总统计数据区分正常眼和青光眼眼的能力优于标准视盘参数杯盘比、视盘边缘面积和杯体积。相对NFL高度的测量与视野丧失指数相关；最强的相关性出现在上极和下极的测量中。视乳头旁NFL高度的测量可能有助于早期检测青光眼性视神经损伤，并随着时间的推移准确识别进行性神经损伤。
