Caprioli J, Miller J M
Department of Ophthalmology and Visual Sciences, Yale University School of Medicine, New Haven, CT 06510.
Ophthalmology. 1988 Jun;95(6):723-7. doi: 10.1016/s0161-6420(88)33116-7.
The relationship between quantitative structural measurements of the optic nerve head and quantitative measurements of the visual field in glaucoma was studied. Computerized videographic image analysis (Rodenstock Analyzer) was used to obtain cup-disc ratio, disc rim area, and cup volume in 50 glaucoma suspects and 37 glaucoma patients. The visual field indices, mean defect and loss standard deviation, were calculated from Octopus Program 32. There were statistically significant linear correlations between each of the optic nerve structural parameters and visual field mean defect and loss standard deviation. The strongest correlation was between disc rim area and visual field mean defect (r = -0.49), which are both global measures of glaucomatous damage. The correlations were not strong enough to readily allow the recognition of early nerve damage by the parameters analyzed thus far. Closer correlations may be evident if structural parameters can be found that more accurately reflect the number of surviving axons in the optic nerve head.
研究了青光眼患者视神经乳头定量结构测量与视野定量测量之间的关系。使用计算机视频图像分析（罗敦司得分析仪）获取50名青光眼疑似患者和37名青光眼患者的杯盘比、视盘边缘面积和杯体积。视野指标，即平均缺损和损失标准差，通过Octopus程序32计算得出。每个视神经结构参数与视野平均缺损和损失标准差之间均存在统计学上显著的线性相关性。最强的相关性存在于视盘边缘面积与视野平均缺损之间（r = -0.49），二者均为青光眼性损害的整体测量指标。这些相关性还不够强，无法通过目前分析的参数轻易识别早期神经损伤。如果能够找到更准确反映视神经乳头中存活轴突数量的结构参数，可能会有更密切的相关性。
