Carpentier Kathryn S, Geballe Adam P
Departments of Microbiology and Medicine, University of Washington, Seattle, Washington, USA Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Departments of Microbiology and Medicine, University of Washington, Seattle, Washington, USA Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
J Virol. 2016 Jan 20;90(7):3280-3. doi: 10.1128/JVI.01996-15.
To establish productive infections, viruses must counteract numerous cellular defenses that are poised to recognize viruses as nonself and to activate antiviral pathways. The opposing goals of host and viral factors lead to evolutionary arms races that can be illuminated by evolutionary and computational methods and tested in experimental models. Here we illustrate how this perspective has been contributing to our understanding of the interactions of the protein kinase R pathway with large DNA viruses.
为了建立有效的感染，病毒必须对抗众多细胞防御机制，这些防御机制随时准备将病毒识别为非自身物质并激活抗病毒途径。宿主和病毒因子的相反目标导致了进化军备竞赛，这可以通过进化和计算方法来阐明，并在实验模型中进行测试。在这里，我们阐述了这种观点如何有助于我们理解蛋白激酶R途径与大型DNA病毒的相互作用。
