雷帕霉素靶蛋白复合物1的结构见解
Structural insights of mTOR complex 1.
作者信息
Yuan Hai-Xin, Guan Kun-Liang
机构信息
Molecular Cell Biology Laboratory, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
出版信息
Cell Res. 2016 Mar;26(3):267-8. doi: 10.1038/cr.2016.10. Epub 2016 Jan 22.
Abstract
The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin, is a central cell growth regulating kinase that forms large molecular complexes in all eukaryotic cells. A paper recently published in Science reports the architecture of mTOR complex 1 (mTORC1) and provides molecular insights into the regulation and substrate selectivity of mTORC1.
摘要
雷帕霉素哺乳动物靶蛋白（mTOR），也称为雷帕霉素作用机制靶蛋白，是一种核心的细胞生长调节激酶，在所有真核细胞中形成大分子复合物。最近发表在《科学》杂志上的一篇论文报道了mTOR复合物1（mTORC1）的结构，并提供了关于mTORC1调节和底物选择性的分子见解。
相似文献
1
Structural insights of mTOR complex 1.雷帕霉素靶蛋白复合物1的结构见解
Cell Res. 2016 Mar;26(3):267-8. doi: 10.1038/cr.2016.10. Epub 2016 Jan 22.
2
Architecture of human mTOR complex 1.人 mTOR 复合物 1 的结构。
Science. 2016 Jan 1;351(6268):48-52. doi: 10.1126/science.aaa3870. Epub 2015 Dec 17.
3
CELL SIGNALING. Seeing mTORC1 specificity.细胞信号传导。洞察mTORC1的特异性。
Science. 2016 Jan 1;351(6268):25-6. doi: 10.1126/science.aad9696.
4
4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1.人源mTOR复合物1的4.4埃分辨率冷冻电镜结构
Protein Cell. 2016 Dec;7(12):878-887. doi: 10.1007/s13238-016-0346-6. Epub 2016 Dec 1.
5
PIKKs--the solenoid nest where partners and kinases meet.PIKKs——伙伴和激酶相遇的螺旋巢。
Curr Opin Struct Biol. 2014 Dec;29:134-42. doi: 10.1016/j.sbi.2014.11.003. Epub 2014 Dec 3.
6
Chemical manipulation of the mTORC1 pathway in industrially relevant CHOK1 cells enhances production of therapeutic proteins.在工业相关的CHO-K1细胞中对mTORC1通路进行化学调控可提高治疗性蛋白质的产量。
Biotechnol J. 2015 Jul;10(7):1041-50. doi: 10.1002/biot.201500075. Epub 2015 Jun 25.
7
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.依赖磷脂酰肌醇-3,4,5-三磷酸（PtdIns(3,4,5)P3）激活雷帕霉素靶蛋白复合物2（mTORC2）激酶
Cancer Discov. 2015 Nov;5(11):1194-209. doi: 10.1158/2159-8290.CD-15-0460. Epub 2015 Aug 20.
8
Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2.雷帕霉素独立于mTORC1和mTORC2抑制mSin1磷酸化。
Oncotarget. 2015 Feb 28;6(6):4286-98. doi: 10.18632/oncotarget.3006.
9
Determination of mTORC1 Complex Structures Reveals Regulatory Mechanisms.解析 mTORC1 复合物结构揭示调控机制。
Cancer Discov. 2018 Feb;8(2):OF11. doi: 10.1158/2159-8290.CD-RW2018-001. Epub 2018 Jan 5.
10
Steady-state kinetic and inhibition studies of the mammalian target of rapamycin (mTOR) kinase domain and mTOR complexes.哺乳动物雷帕霉素靶蛋白（mTOR）激酶结构域及其复合物的稳态动力学和抑制研究。
Biochemistry. 2010 Oct 5;49(39):8488-98. doi: 10.1021/bi100673c. Epub 2010 Sep 8.
引用本文的文献
1
The TXNIP-mTOR-Autophagy axis in diabetic kidney disease: mechanistic insights and therapeutic implications.糖尿病肾病中的TXNIP-mTOR-自噬轴：机制洞察与治疗意义
Mol Biol Rep. 2025 Aug 21;52(1):839. doi: 10.1007/s11033-025-10946-w.
2
Integrative Multi-PTM Proteomics Reveals Dynamic Global, Redox, Phosphorylation, and Acetylation Regulation in Cytokine-Treated Pancreatic Beta Cells.整合多翻译后修饰蛋白质组学揭示细胞因子处理的胰岛β细胞中的动态全局、氧化还原、磷酸化和乙酰化调控
Mol Cell Proteomics. 2024 Dec;23(12):100881. doi: 10.1016/j.mcpro.2024.100881. Epub 2024 Nov 15.
3
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease.mTOR（哺乳动物雷帕霉素靶蛋白）信号通路在人类健康和疾病中的多方面作用。
Signal Transduct Target Ther. 2023 Oct 2;8(1):375. doi: 10.1038/s41392-023-01608-z.
4
A Novel Bioactive Peptide, T14, Selectively Activates mTORC1 Signalling: Therapeutic Implications for Neurodegeneration and Other Rapamycin-Sensitive Applications.一种新型生物活性肽 T14 选择性激活 mTORC1 信号：对神经退行性变和其他雷帕霉素敏感应用的治疗意义。
Int J Mol Sci. 2023 Jun 9;24(12):9961. doi: 10.3390/ijms24129961.
5
Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma.长链非编码 RNA（lncRNAs）作为胃癌中 PI3K/AKT/mTOR 通路的调节剂。
Int J Mol Sci. 2023 Mar 27;24(7):6294. doi: 10.3390/ijms24076294.
6
Regulation of mTOR by phosphatidic acid.磷脂酸对 mTOR 的调节。
Trends Endocrinol Metab. 2023 Mar;34(3):170-180. doi: 10.1016/j.tem.2023.01.004. Epub 2023 Jan 31.
7
Mechanistic target of rapamycin inhibitors: successes and challenges as cancer therapeutics.雷帕霉素作用机制靶点抑制剂：作为癌症治疗药物的成功与挑战
Cancer Drug Resist. 2019 Dec 19;2(4):1069-1085. doi: 10.20517/cdr.2019.87. eCollection 2019.
8
eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage.eIF3a 通过 HuR 调控 mTOR 信号和翻译控制在细胞对 DNA 损伤的反应中的作用。
Oncogene. 2022 Apr;41(17):2431-2443. doi: 10.1038/s41388-022-02262-5. Epub 2022 Mar 12.
9
Targeting the PI3K/AKT/mTOR Signaling Pathway in Lung Cancer: An Update Regarding Potential Drugs and Natural Products.针对肺癌中的 PI3K/AKT/mTOR 信号通路：关于潜在药物和天然产物的最新研究。
Molecules. 2021 Jul 5;26(13):4100. doi: 10.3390/molecules26134100.
10
Autophagy modulation as a potential targeted cancer therapy: From drug repurposing to new drug development.自噬调控作为一种潜在的靶向癌症治疗方法：从药物再利用到新药开发。
Kaohsiung J Med Sci. 2021 Mar;37(3):166-171. doi: 10.1002/kjm2.12361. Epub 2021 Jan 26.
本文引用的文献
1
Architecture of human mTOR complex 1.人 mTOR 复合物 1 的结构。
Science. 2016 Jan 1;351(6268):48-52. doi: 10.1126/science.aaa3870. Epub 2015 Dec 17.
2
mTOR kinase structure, mechanism and regulation.mTOR 激酶结构、机制与调控。
Nature. 2013 May 9;497(7448):217-23. doi: 10.1038/nature12122. Epub 2013 May 1.
3
mTOR signaling in growth control and disease.mTOR 信号在生长控制和疾病中的作用。
Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017.
4
Rapamycin passes the torch: a new generation of mTOR inhibitors.雷帕霉素传递火炬：新一代 mTOR 抑制剂。
Nat Rev Drug Discov. 2011 Oct 31;10(11):868-80. doi: 10.1038/nrd3531.
5
Structure of the human mTOR complex I and its implications for rapamycin inhibition.人 mTOR 复合物 I 的结构及其对雷帕霉素抑制的影响。
Mol Cell. 2010 Jun 11;38(5):768-74. doi: 10.1016/j.molcel.2010.05.017.
6
Molecular mechanisms of mTOR-mediated translational control.mTOR介导的翻译控制的分子机制。
Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. doi: 10.1038/nrm2672. Epub 2009 Apr 2.
Zotero 插件