Yuan Hai-Xin, Guan Kun-Liang
Molecular Cell Biology Laboratory, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.
Cell Res. 2016 Mar;26(3):267-8. doi: 10.1038/cr.2016.10. Epub 2016 Jan 22.
The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin, is a central cell growth regulating kinase that forms large molecular complexes in all eukaryotic cells. A paper recently published in Science reports the architecture of mTOR complex 1 (mTORC1) and provides molecular insights into the regulation and substrate selectivity of mTORC1.
雷帕霉素哺乳动物靶蛋白（mTOR），也称为雷帕霉素作用机制靶蛋白，是一种核心的细胞生长调节激酶，在所有真核细胞中形成大分子复合物。最近发表在《科学》杂志上的一篇论文报道了mTOR复合物1（mTORC1）的结构，并提供了关于mTORC1调节和底物选择性的分子见解。
