Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, UK.
Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, UK.
Psychiatry Res. 2016 Feb 28;236:182-185. doi: 10.1016/j.psychres.2016.01.017. Epub 2016 Jan 8.
We have previously reported an association between childhood sexual trauma and transition to psychosis in an Ultra High Risk (UHR) population. We aimed to investigate if this association was mediated by affective or dissociative symptoms. Data were from a large UHR for psychosis cohort study. None of the potential mediators (depression, anxiety, dissociation, mood swings and mania, assessed by the HAM-D, HAM-A and the CAARMS symptom scales) significantly mediated the total association between sexual abuse scores and transition. At the point of transition, the mechanistic pathway from sexual trauma to psychosis does not appear to operate through affective symptoms.
我们之前曾报道过儿童期性创伤与超高危（UHR）人群精神分裂症转化之间的关联。我们旨在调查这种关联是否通过情感或分离症状来介导。数据来自于一项大型的精神分裂症超高危人群队列研究。在性虐待评分与转化之间的总关联中，没有任何潜在的中介因素（通过 HAM-D、HAM-A 和 CAARMS 症状量表评估的抑郁、焦虑、分离、情绪波动和躁狂）具有显著的中介作用。在转化点，性创伤到精神分裂症的机制途径似乎不是通过情感症状起作用的。
