*To whom correspondence should be addressed; East Sussex Early Intervention Service, Sussex Partnership NHS Foundation Trust, Sussex Education Centre, Mill View Hospital, Nevill Avenue, Hove, BN3 7HZ, UK; tel: +441323446062, fax: 01323446064, e-mail:
Schizophr Bull. 2014 May;40(3):697-706. doi: 10.1093/schbul/sbt032. Epub 2013 Mar 2.
Studies indicate a high prevalence of childhood trauma in patient cohorts with established psychotic disorder and in those at risk of developing psychosis. A causal link between childhood trauma and development of psychosis has been proposed. We aimed to examine the association between experience of childhood trauma and the development of a psychotic disorder in a large "Ultra High Risk" (UHR) for psychosis cohort. The data were collected as part of a longitudinal cohort study of all UHR patients recruited to research studies at the Personal Assessment and Clinical Evaluation clinic between 1993 and 2006. Baseline data were collected at recruitment to these studies. The participants completed a comprehensive follow-up assessment battery (mean time to follow-up 7.5 years, range 2.4-14.9 years), which included the Childhood Trauma Questionnaire (CTQ), a self-report questionnaire that assesses experience of childhood trauma. The outcome of interest was transition to a psychotic disorder during the follow-up period. Data were available on 233 individuals. Total CTQ trauma score was not associated with transition to psychosis. Of the individual trauma types, only sexual abuse was associated with transition to psychosis (P = .02). The association remained when adjusting for potential confounding factors. Those with high sexual abuse scores were estimated to have a transition risk 2-4 times that of those with low scores. The findings suggest that sexual trauma may be an important contributing factor in development of psychosis for some individuals.
研究表明，在已确诊精神病的患者群体和有精神病发病风险的患者群体中，童年创伤的发生率很高。有人提出，童年创伤与精神病的发展之间存在因果关系。我们旨在研究童年创伤经历与大量“超高风险”（UHR）精神病患者发展为精神病之间的关联。该数据是作为 1993 年至 2006 年间在个人评估和临床评估诊所招募的所有 UHR 患者纵向队列研究的一部分收集的。这些研究的招募阶段收集了基线数据。参与者完成了全面的随访评估工具包（平均随访时间为 7.5 年，范围为 2.4-14.9 年），其中包括童年创伤问卷（CTQ），这是一种自我报告问卷，用于评估童年创伤经历。研究关注的结果是在随访期间转为精神病。共 233 人可提供数据。CTQ 总创伤评分与向精神病的转变无关。在个别创伤类型中，只有性虐待与向精神病的转变有关（P =.02）。在调整潜在混杂因素后，该关联仍然存在。那些性虐待评分较高的人被估计有 2-4 倍的转换风险。研究结果表明，对于某些人来说，性创伤可能是精神病发展的一个重要因素。
